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PRDX2 — TNF

Text-mined interactions from Literome

Yao et al., Pharmacol Res 2006 (Carcinoma...) : Coincident with this observation, TSA induced a concentration dependent reduction of constitutive and tumour necrosis factor (TNF)-alpha induced NF-kappaB activation in Tca8113 cells
Chang et al., Mol Immunol 2007 : The biological experiments demonstrated that TSA1 could directly bind with TNF-alpha, competitively inhibit the binding of mAb Z12 to TNF-alpha and block the binding of TNF-alpha to TNFR I and TNFR II
Zabłocka et al., Int Immunopharmacol 2007 : On the other hand, the release of TNF-alpha and IL-10 induced by LP in PBMCs was inhibited by PRP while NP inhibited the release of IFN-gamma and IL-10
Dombrowsky et al., Eur Respir J 2007 : In the presence or absence of dexamethasone, TSA enhanced overventilation induced induction of TNF and MIP-2alpha, but decreased that of IL-6, indicating that the effects of HDAC are gene dependent
Wang et al., J Biol Chem 2007 (Thrombosis) : In human umbilical vein endothelial cells, TSA attenuates by approximately 70 % TNF-alpha stimulation of TF mRNA transcription without affecting that of ICAM-1
Dombrowsky et al., Pulm Pharmacol Ther 2009 (Lung Diseases) : At the protein level, TSA reduced the stimulated release of TNF , MIP-2alpha and IL-6, indicating that TSA may affect protein translation independent from gene transcription
Wu et al., Gynecol Obstet Invest 2010 (Endometriosis) : TNFalpha stimulation activated NF-kappaB through induction of IkappaB phosphorylation, but the activation can be suppressed by TSA
Salvi et al., Immunobiology 2010 (Lupus Erythematosus, Systemic) : TSA inhibited the production of IFN-I, TRAIL and of the pro-inflammatory cytokines TNFalpha and IL-6 by CpG activated PDC
Chen et al., PloS one 2012 (Brain Ischemia...) : ELISA demonstrated that TSA could inhibit MIF expression and the release of TNF-a and IL-6 induced by I/R injury
Zhang et al., Int Immunopharmacol 2012 (Hemolysis) : The Con A-, LPS-, and OVA induced splenocyte proliferation, OVA-specific antibody levels ( IgG, IgG1, IgG2a and IgG2b ) and IFN-?, TNF-a , IL-2, IL-4 and IL-5 in serum were significantly enhanced by TSA2 ( 25 µg/mouse )