Jubier-Maurin et al., Infect Immun 2001
:
Major outer membrane protein Omp25 of Brucella suis is involved in inhibition of tumor necrosis factor alpha production during infection of human macrophages ... These observations demonstrated that Omp25 of B. suis is involved in the negative regulation of TNF-alpha production upon infection of human macrophages
Dornand et al., Vet Microbiol 2002
(Brucellosis) :
It is likely that the Omp25 induced effect on TNF-alpha production assists bacterial evasion of antimicrobial defences at different levels
Asakawa et al., Mol Microbiol 2003
(Actinobacillus Infections...) :
Omp100 induced inflammatory cytokine responses of interleukin (IL)-8, IL-6 and tumour necrosis factor (TNF)alpha in epithelial cells, and induced IL-1beta and TNFalpha production in mouse macrophages
Billard et al., Infect Immun 2007
:
In light of these data, we propose a model in which virulent Brucella alters the maturation and functions of DCs through Omp25 dependent control of TNF-alpha production