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CCR5 — TNF

Text-mined interactions from Literome

Vecchi et al., J Leukoc Biol 1999 : TNF-alpha down-regulated CC chemokine receptor (CCR)1, CCR2, and CCR5 and up-regulated CCR7 mRNA levels, in agreement with functional data
Sato et al., J Immunol 2000 : Stimulation of mature DCs with TGF-beta 1 also enhanced TNF-alpha induced down-regulation of the expressions of CCR-1, CCR-3, CCR-5 , CCR-6, and CXCR-4, and chemotaxis to their respective ligands, while this stimulation suppressed TNF-alpha induced expression of CCR-7 and chemotactic migratory ability to MIP-3 beta
Saccani et al., Proc Natl Acad Sci U S A 2000 : In contrast, xanthine/xanthine oxidase opposed the bacterial lipopolysaccharide- and tumor necrosis factor-alpha mediated inhibition of CCR5 and CXCR4 mRNA expression and increased both the CCR5 surface expression and the cell migration ( 3-fold ) in response to macrophage inflammatory protein-1beta
Bailer et al., Eur J Immunol 2000 : In the presence of IL-13 and TNF-alpha , expression of CCR5 was completely abrogated while the expression of CD4 and CXCR4 remained significantly reduced as compared to untreated controls
Zhao et al., J Oral Pathol Med 2002 (Lichen Planus) : TNF-alpha stimulated CCR1, CCR4 and CCR5 mRNA expression in the same cell line
Croitoru-Lamoury et al., Glia 2003 : Expression of chemokines and their receptors in human and simian astrocytes : evidence for a central role of TNF alpha and IFN gamma in CXCR4 and CCR5 modulation ... Moreover, TNFalpha and IL-1beta significantly increase BOB/GPR15, CCR2 , and V28/CX3CR1 mRNA levels in both models
Ponte et al., Stem Cells 2007 : TNFalpha increases CCR2, CCR3 , and CCR4 expression ( as opposed to that of CXCR4 ), together with RANTES membrane binding
Venza et al., J Periodontol 2010 (Chronic Periodontitis...) : These findings showed that : 1 ) in subjects without diabetes and patients with well controlled diabetes, TNF-alpha, CCR5 , and CXCR3 may constitute distinctive biomarkers of P-IM; 2 ) poor glycemic control abolished the differences between CP and P-IM regarding the expression of these mediators ; and 3 ) type 2 diabetes affected the expression of TNF-alpha , IL-6 and -8, CCR5, and CXCR3
Catley et al., IDrugs 2010 (Asthma...) : This conference report highlights selected presentations on mAb treatments for asthma, including targeting IL-5, IL-13, IL-9 and TNFa , CCR3 inhibitors , histamine H4 receptor inhibition, novel mouse models of COPD and inhaled antisense asthma therapies