Gurgui et al., Cell Signal 2010
:
Although our experimental data clearly show the mediatory role of sphingosine kinase ( SK ) -derived S1P in the TNF-alpha and the LPS induced activation of NF-kB, exogenously added S1P failed to trigger this transcription factor
Fischer et al., PloS one 2011
(Inflammation...) :
Activation of SphK by LPS stimulation was confirmed by SphK activity assay and was blocked by the use of the SphK inhibitor SKI ( 2- ( p-hydroxyanilino ) -4- ( p-chlorphenyl ) thiazole