Zhang et al., Cancer Biol Ther 2009
:
PIM1 protein kinase overexpression reduced the association of PRAS40 with mTOR, and increased the mTOR directed phosphorylation of 4EBP1 and p70S6Kinase
Asano et al., Leukemia 2011
(Multiple Myeloma) :
The Pim inhibitor suppresses 4E-BP1 phosphorylation along with the reduction of Mcl-1 and c-Myc