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IL6 — SST

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Kang et al., Regul Pept 2001 : Recent studies have shown that somatostatin (SOM) inhibits interleukin 6 (IL-6) and interferon gamma (IFNgamma) production by lymphocytes and peritoneal macrophages, whereas substance P ( SP ) enhances these cytokines production
Andoh et al., Int J Mol Med 2002 (Acute Disease...) : Inhibitory effects of somatostatin on tumor necrosis factor-alpha induced interleukin-6 secretion in human pancreatic periacinar myofibroblasts ... To elucidate the mechanisms mediating the therapeutic actions of somatostatin on acute pancreatitis, we investigated how somatostatin affects the tumor necrosis factor (TNF)-alpha induced interleukin (IL)-6 and IL-8 secretion from pancreatic myofibroblasts ... Somatostatin dose-dependently inhibited the TNF-alpha induced IL-6 secretion ... Northern blot analysis demonstrated that somatostatin decreased the TNF-alpha induced IL-6 mRNA expression, and that this effect was completely blocked by the somatostatin antagonist cyclo-somatostatin ... Somatostatin down-regulated the TNF-alpha induced IL-6 secretion in human pancreatic periacinar myofibroblasts
Zhu et al., Zhonghua Yi Xue Za Zhi 2007 (Disease Models, Animal...) : [ The effects of somatostatin on serum interleukin-6 and tumor necrosis factor-alpha in lipopolysaccharide induced septic shock : experiment with rats ] ... To explore the effect of somatostatin on serum interleukin (IL)-6 and tumor necrosis factor (TNF)-alpha in lipopolysaccharide (LPS) induced septic shock ... Somatostatin can inhibit the level of serum IL-6 and TNF-alpha in septic shock induced by LPS and improve the survival rate
Spangelo et al., Endocrinology 1990 : The presence of IL-6 in the hypothalamus suggested a possible role for this cytokine in the regulation of neuropeptide release ; however, the release of somatostatin was not affected by 20 ng/ml IL-6
Vindeløv et al., Growth Horm IGF Res 2011 (Adenoma...) : The cultured adenoma cells released both IL-6 and IL-8 and the secretion was inhibited by GHRH and somatostatin
Hernanz et al., J Neuroimmunol 1996 : Differential effects of gastrin releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects ... Differential effects of gastrin releasing peptide, neuropeptide Y, somatostatin and vasoactive intestinal peptide on interleukin-1 beta, interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects ... In the present study, we have investigated the effect in vitro of gastrin releasing peptide ( GRP, 10 ( -10 ) M ), neuropeptide Y ( NPY, 10 ( -10 ) M ), somatostatin ( 10 ( -10 ) M ) and vasoactive intestinal peptide ( VIP, 10 ( -9 ) M ) on the production of IL-1 beta, IL-6 and TNF alpha by peripheral whole blood cells from healthy young and old people
Grimaldi et al., Biochem Biophys Res Commun 1997 : Somatostatin inhibits interleukin 6 release from rat cortical type I astrocytes via the inhibition of adenylyl cyclase ... The aim of this study was to characterize the effects of somatostatin on the release of interleukin 6 from rat cortical type I astrocytes and the intracellular mechanisms involved in this activity ... Our results show that somatostatin , in a concentration dependent manner, inhibited basal and forskolin stimulated interleukin 6 release from rat cortical type I astrocytes in culture ... To identify the intracellular mechanism mediating the effects of somatostatin on the interleukin 6 release, we evaluated the peptide modulation of basal and stimulated intracellular accumulation of cAMP ... Conversely, somatostatin did not affect the increase of interleukin 6 release induced by dibutyryl-cAMP, a nonhydrolizable cAMP analog that, bypassing the effects of somatostatin on adenylyl cyclase activity, directly activated protein kinase A ... In conclusion, our data demonstrate that the release of interleukin 6 from rat cortical type I astrocytes is inhibited by somatostatin through the activation of a somatostatin receptor coupled to the inhibition of adenylyl cyclase via a G-protein sensitive to pertussis toxin