Gene interactions and pathways from curated databases and text-mining

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ATP5O — VCP

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Kumar et al., J Neural Transm 2001 : Membrane Na+-K+ ATPase inhibition can result in increased intracellular Ca2+ and reduced magnesium levels ... Membrane Na+-K+ ATPase inhibition can produce immune activation, a component of autoimmunity
Kurup et al., Neurosci Res 2002 (Basal Ganglia Diseases...) : Membrane sodium-potassium ATPase inhibition can lead on to increase in intracellular calcium and calcification of the basal ganglia
Kurup et al., J Exp Clin Cancer Res 2001 (Astrocytoma...) : Membrane Na+-K+ ATPase inhibition due to elevated digoxin, altered membrane structure and digoxin related tyrosine / tryptophan transport defect leading to increased levels of depolarising tryptophan catabolites and decreased levels of hyperpolarising tyrosine catabolites can lead to alteration in intracellular calcium/magnesium ratios and oncogene activation
Kumar et al., Indian J Physiol Pharmacol 2001 (Epilepsy, Generalized...) : Membrane Na+ K+ ATPase inhibition related dyslipidemia and insulin resistance in neuropsychiatric disorders
Kumar et al., J Assoc Physicians India 2001 (Metabolic Syndrome X) : Membrane Na+-K+ ATPase inhibition due to digoxin, altered membrane structure, increased tryptophan catabolites and decreased tyrosine catabolites can lead on to increased intracellular calcium and reduced intracellular magnesium which can account for the symptoms of syndrome X
Kurup et al., Arch Androl 2002 : Membrane Na ( + ) -K ( + ) ATPase inhibition leads to increase in intracellular calcium and upregulated nitric oxide synthesis
Kurup et al., Int J Neurosci 2003 : Membrane Na+-K+ ATPase inhibition mediated quantal model for brain evolution
Kurup et al., Int J Neurosci 2003 : Membrane Na+-K+ ATPase inhibition can result in increased intracellular Ca2+ and reduced magnesium levels ... Membrane Na+-K+ ATPase inhibition can produce immune activation, a component of autoimmunity
Song et al., Biochemistry 2007 : Together, these results indicate that ( 1 ) VCP prevents protein aggregation in vitro and in vivo, ( 2 ) this aggregation-prevention activity is mediated mainly through the D1 domain of VCP, and ( 3 ) this activity does not require ATPase activity or a hexameric structure of VCP
Griciuc et al., Biochim Biophys Acta 2010 (Retinitis Pigmentosa) : VCP co-localizes with misfolded Rh ( P23H ) in retinal cells and requires functional N-terminal and D1 ATPase domains to form a complex with Rh ( P23H ) aggregates
Anderson et al., J Physiol 2010 : Membrane voltage responses of FS cells to Na ( + ) -K ( + ) ATPase blockade were intermediate between the two PYR cell groups ( P < 0.05 )