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PLD5 — RALA

Text-mined interactions from Literome

Lu et al., Mol Cell Biol 2000 (Cell Transformation, Neoplastic) : The activation of PLD by EGF in these cells was dependent upon both Ras and RalA ... Importantly, overexpression of wild-type RalA or an activated RalA mutant increased PLD activity in the absence of EGF and transformed the EGFR cells
Henry et al., Mol Cell Biol 2000 : Ral activation of these responses is likely through an as yet uncharacterized effector pathway, as we find activation of NF-kappaB and the cyclin D1 promoter by Ral is independent of association of Ral with active phospholipase D1 or Ral binding protein 1, two proteins proposed to mediate Ral function in cells
Xu et al., Mol Cell Biol 2003 : PLD activity in H-Ras transformed cells is dependent upon RalA , and consistent with a lack of elevated PLD activity in K-Ras transformed cells, RalA was not activated in K-Ras transformed cells ... Although H-Ras induced PLD activity is dependent upon RalA , an activated mutant of RalA is not sufficient to elevate PLD activity ... Activated mutants of either ARF6 or RalA were not sufficient to elevate PLD activity in NIH 3T3 cells ; however, expression of both activated RalA and activated ARF6 in NIH 3T3 cells led to increased PLD activity
Garcia et al., Clin Cancer Res 2008 (Neoplasms) : The PLD activity was also dependent on the GTPases RalA and ADP ribosylation factor
Corrotte et al., J Immunol 2010 : Ral isoforms are implicated in Fc gamma R-mediated phagocytosis : activation of phospholipase D by RalA
Xu et al., J Biol Chem 2011 : Amino acid- and glucose induced PLD and mTORC1 activity were also dependent on the GTPases RalA and ARF6 and the type III phosphatidylinositol-3-kinase hVps34
Jiang et al., Nature 1995 : Overexpression of RalA potentiated PLD activation by v-Src, and expression of dominant negative RalA mutants inhibited both v-Src- and v-Ras induced PLD activity
Luo et al., Proc Natl Acad Sci U S A 1998 : Brefeldin A, which inhibits Arf GDP-GTP exchange, inhibited PLD activity in v-Src- and v-Ras transformed cells but not in the nontransformed cells, suggesting that the association of Arf with RalA is required for the increased PLD activity induced by v-Src and v-Ras
Kim et al., FEBS Lett 1998 : Activation of phospholipase D1 by direct interaction with ADP-ribosylation factor 1 and RalA ... We found that RalA , another member of the small GTP binding proteins, synergistically enhances the ARF1 dependent PLD activity with an EC50 of about 30 nM