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NOTCH1 — SHH

Text-mined interactions from Literome

Androutsellis-Theotokis et al., Nature 2006 (Second Messenger Systems) : Here we show that Notch receptor activation induces the expression of the specific target genes hairy and enhancer of split 3 (Hes3) and Sonic hedgehog (Shh) through rapid activation of cytoplasmic signals, including the serine/threonine kinase Akt, the transcription factor STAT3 and mammalian target of rapamycin, and thereby promotes the survival of neural stem cells
Crawford et al., Dev Dyn 2007 : During development of the neural tube, inhibition of the Notch response as well as the activation of the Sonic Hedgehog (Shh) response results in the formation of neuronal cell types
Morrow et al., Arterioscler Thromb Vasc Biol 2009 : Recombinant VEGF-A increased Hrt-3 mRNA levels while siRNA knockdown abolished rShh stimulated VEGF-A expression while concomitantly inhibiting Shh induced increases in Hrt-3 mRNA levels, proliferating cell nuclear antigen ( PCNA ), and Notch 1 IC expression, respectively
Li et al., Stem Cells 2012 : Genome-wide analysis of N1ICD/RBPJ targets in vivo reveals direct transcriptional regulation of Wnt, SHH , and hippo pathway effectors by Notch1