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IFNG — TLR1
Text-mined interactions from Literome
Gu et al., Zhonghua Wai Ke Za Zhi 1997
(Stomach Neoplasms) :
The
effects of
IFN-gamma on
TIL and LAK cytotoxicities on K562 tumor cell line and MKN45 gastric cancer tumor were observed
Miettinen et al., Genes Immun 2001
:
IFN-gamma enhanced the expression of
TLR1 and TLR2 mRNA in macrophages, and TLR3 in epithelial and endothelial cells
Radoja et al., J Immunol 2001
:
In
response to TCR ligation of nonlytic
TIL in vitro, proximal and distal signaling events are normal ; calcium flux is rapid ; mitogen activated protein/extracellular signal related kinase kinase, extracellular regulatory kinase 2, phosphoinositide-3 kinase, and protein kinase C are activated ; and IL-2 and
IFN-gamma is secreted
Krutzik et al., Nat Med 2003
(Leprosy) :
In addition,
interferon (IFN)-gamma and granulocyte-macrophage colony stimulating factor ( GM-CSF )
enhanced TLR1 expression in monocytes and dendritic cells, respectively, whereas IL-4 downregulated TLR2 expression
Pai et al., Infect Immun 2004
:
Microarray gene expression studies were then used to determine whether prolonged
TLR signaling by M. tuberculosis broadly
inhibits IFN-gamma regulation of macrophage gene expression
Mueller et al., J Immunol 2006
:
The down-regulatory effect of Th2 cytokines on TLR expression and function in IECs also counteracted enhanced
TLR signaling
induced by stimulation with the hallmark Th1 cytokine
IFN-gamma
Eriksson et al., J Immunol 2006
:
However, purified uNK cells did not respond directly to TLR agonists, but
IFN-gamma was produced by uNK cells in
response to
TLR stimulation when cocultured with APCs
Velayudham et al., J Hepatol 2006
(Granuloma...) :
IFNgamma induction by P. acnes,
TLR2 and TLR9 ligands required MyD88
Ramakers et al., Cytokine 2006
:
In more detail, CPA potentiated TLR5 mediated IL-6 production,
TLR3 mediated
IFN-gamma production and TLR3 mediated Il-1beta production compared to TLR4 mediated stimulation
Girart et al., J Immunol 2007
(Melanoma) :
Engagement of TLR3,
TLR7 , and NKG2D
regulate IFN-gamma secretion but not NKG2D mediated cytotoxicity by human NK cells stimulated with suboptimal doses of IL-12
Barr et al., Eur J Immunol 2007
:
In this study, we investigated which mouse B cell subsets are the most potent cytokine producers, and examined the
role of
Toll-like receptors ( TLR ) in the control of secretion of IL-6, IL-10, IL-12 and
IFN-gamma by B cells ... Thus, in
response to combined
TLR stimulation, or via phorbol esters,
IFN-gamma was secreted
Allam et al., J Allergy Clin Immunol 2008
:
Moreover,
TLR4-ligation on oLCs
induced IL-10, TGF-beta1, Forkhead box protein 3,
IFN-gamma , and IL-2 production in T cells
O'Mahony et al., International journal of medical sciences 2008
:
Of the cytokines examined,
IFN-gamma and GM-CSF
caused the greatest effects on
TLR expression
Prescott et al., J Allergy Clin Immunol 2008
(Hypersensitivity...) :
Maternal allergy ( n = 59 ) was associated with significantly higher neonatal IL-12 and
IFN-gamma responses to TLR2,
TLR3 , and TLR4 activation, whereas TNF-alpha and IL-6 responses to TLR2, TLR4, and TLR5 activation were significantly higher in newborns who subsequently had allergic disease ( n = 32 )
Archer et al., Cell Microbiol 2009
:
Thus, MyD88 dependent innate immune responses induced by L. pneumophila involve both
TLR dependent responses and IL-18R dependent production of
IFN-gamma by natural killer cells, and these MyD88 dependent pathways can function independently to provide host protection against an intracellular pathogen
Onishi et al., Br J Urol 1991
(Kidney Neoplasms) :
The
effect of
IFN-gamma on
TIL was an increase in CD3 ( pan-T cells ), especially an increase in CD8 ( cytotoxic/suppressor-T cells )
Yarovinsky et al., J Immunol 2008
(Acute Disease...) :
We further show that this immunopathology is the result of
non-TLR dependent activation of
IFN-gamma secretion by NK cells in response to the infection
Lotter et al., PLoS Pathog 2009
(Disease Models, Animal...) :
IFN-gamma production by NKT cells
requires the presence of CD1d and simultaneously
TLR receptor signalling through MyD88 and secretion of IL-12
Devilder et al., J Immunol 2009
:
Moreover
TLR induced Vgamma9Vdelta2
IFN-gamma noncytolytic response led to efficient DC polarization into IL-12p70 producing cells
Lee et al., J Parasitol 2010
:
We also performed reverse transcriptase-polymerase chain reaction ( RT-PCR ) and flow cytometry to determine whether
TLR and MUC expression is
regulated by interferon
(IFN)-gamma , interleukin-4, or monoclonal antibodies ( mAbs ) against G. seoi 46 kDa antigen
van Hoffen et al., Int Arch Allergy Immunol 2010
:
Apically added LGG,
TLR2 and NOD2 ligands, but not Bb,
enhanced IFN-gamma , IL-12 and/or TNF-alpha secretion
Fang et al., FEMS Immunol Med Microbiol 2010
(West Nile Fever) :
Viral antigens were detected in WNV infected gammadelta T cells.WNV infection or
toll-like receptor ( TLR ) agonist treatment of gammadelta T cells
induced the production of
IFN-gamma , tumor necrosis factor-alpha and IL-6, which are known to promote DC maturation
Brisbin et al., Benef Microbes 2012
:
The results demonstrated that chicken CD4+ and CD8+ T-cells express
TLR21 and that the various isolates of lactobacilli differentially
induces the expression of interleukin 10,
interferon-gamma and transforming growth factor beta
Anderson et al., Cancer Immunol Immunother 1987
(Lung Neoplasms) :
This low level of
TIL NK activity was not
affected by
IFN-gamma , INDO, or IL-2 at 1 h
Lüscher et al., Int J Cancer 1994
(Brain Neoplasms...) :
A primary tumor cell line was generated and cultured
TIL were
induced to transcribe IL-2 and
IFN-gamma genes by incubation with the autologous irradiated tumor cell line, but not with autologous EBV transformed cells
Martino et al., Ann Neurol 1998
(Multiple Sclerosis) :
The activation of these pathways, one
activated by
IFNgamma and the other by the combination
TNFalpha/IL-2/IL-6 , is independent from myelin antigens and precedes by 2 weeks phases of disease activity ( eg, clinical relapses and/or appearance of gadolinium enhancing lesions on brain magnetic resonance imaging scans during 1 year of follow-up )
Nagoshi et al., J Immunol 1998
(Sarcoma, Experimental) :
This response was tumor specific since
TIL obtained from MCA-205 did not
induce high levels of
IFN-gamma and GM-CSF and did not induce tumor eradication of MCA-105 tumor