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NGF — ZNF274
Pathways - manually collected, often from reviews:
-
NCI Pathway Database p75(NTR)-mediated signaling:
JNK family (MAPK8/MAPK9/MAPK10)
→
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGF-NGFR-SORT1-TRAF6-ZNF274)
(modification, collaborate)
Khursigara et al., J Neurosci 2001, Gentry et al., J Biol Chem 2004, Yeiser et al., J Neurosci 2004, Linggi et al., J Biol Chem 2005, Casaccia-Bonnefil et al., Nature 1996
Evidence: mutant phenotype, assay, reporter gene, other species
-
NCI Pathway Database p75(NTR)-mediated signaling:
NRIF (ZNF274)
→
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGF-NGFR-SORT1-TRAF6-ZNF274)
(modification, collaborate)
Casademunt et al., EMBO J 1999, Gentry et al., J Biol Chem 2004, Geetha et al., EMBO J 2005
Evidence: assay, physical interaction
-
NCI Pathway Database p75(NTR)-mediated signaling:
NRIF (ZNF274)
→
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 complex (NGF-NGFR-SORT1-TRAF6)
(modification, collaborate)
Casademunt et al., EMBO J 1999, Gentry et al., J Biol Chem 2004, Geetha et al., EMBO J 2005
Evidence: assay, physical interaction
-
NCI Pathway Database p75(NTR)-mediated signaling:
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6/NRIF complex (NGF-NGFR-SORT1-TRAF6-ZNF274)
→
proNGF (dimer)/p75(NTR)/Sortilin/TRAF6 complex (NGF-NGFR-SORT1-TRAF6)
(modification, collaborate)
Casademunt et al., EMBO J 1999, Gentry et al., J Biol Chem 2004, Geetha et al., EMBO J 2005
Evidence: assay, physical interaction
Text-mined interactions from Literome
Heese et al., Exp Mol Med 2004
(Alzheimer Disease...) :
Nerve growth factor (NGF) induces mRNA expression of the new transcription factor protein
p48ZnF ... Additionally, we demonstrate here that
p48ZnF is up-regulated in rat neuronal PC12 cells upon
stimulation with the neurotrophic factor
NGF ( 50 ng/ml )
Changelian et al., Proc Natl Acad Sci U S A 1989
(Adrenal Gland Neoplasms...) :
The NGFI-A gene encodes a ``
zinc-finger '' protein that is rapidly
induced by
nerve growth factor (NGF) in PC12 rat pheochromocytoma cells