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IRS4 — PIK3R1

Pathways - manually collected, often from reviews:

• KEGG Neurotrophin signaling pathway: IRS1/IRS2/IRS4 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Insulin signaling pathway: IRS1/IRS2/IRS4 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Type II diabetes mellitus: IRS1/IRS2/IRS4 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• KEGG Aldosterone-regulated sodium reabsorption: IRS1/IRS2/IRS4 → PIK3CA/PIK3CB/PIK3CD/PIK3CG/PIK3R1/PIK3R2/PIK3R3/PIK3R5 (protein-protein, activation)
  
• WikiPathways Focal Adhesion-PI3K-Akt-mTOR-signaling pathway: IRS1/IRS4/IRS2 → PIK3CA/PIK3R1/PIK3IP1/PIK3R2/PIK3CB/PIK3CD/PIK3R4 (activation)
  

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: IRS4 — PIK3R1 (in vivo) Sano et al., J Biol Chem 2002
• IRef Intact Interaction: Complex of 81 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of 43 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of 18 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Intact Interaction: Complex of 111 proteins (association, tandem affinity purification) Pichlmair et al., Nature 2012
• IRef Ophid Interaction: IRS4 — PIK3R1 (aggregation, interologs mapping) Brown et al., Bioinformatics 2005
• STRING interaction: PIK3R1 — IRS4 (interaction, mapped from grid bind reactome kegg_pathways mint intact)
• STRING interaction: IRS4 — PIK3R1 (interaction, mapped from grid bind reactome kegg_pathways mint intact)

Text-mined interactions from Literome

Villarreal et al., Mol Cell Biochem 2006 : These results suggest that Ins and Ang II modulate IRS-4 tyr-phosphorylation in a PI3K dependent manner
Villarreal et al., Regul Pept 2010 : Role of IRS-4 in PI3-K activation by insulin in HepG2 cells, modulation by Angiotensin II ... We report also Ins induced PI3-K activation mediated by IRS-4