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HSPB1 — PGD
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Kozawa et al., Cell Signal 2001
(MAP Kinase Signaling System) :
PGD ( 2 )
increased the levels of
HSP27 while having little effect on HSP70 levels ...
PGD ( 2 )
induced an increase in the levels of mRNA for
HSP27 ... The
HSP27 accumulation
induced by
PGD ( 2 ) was significantly suppressed by PD98059, an inhibitor of the upstream kinase of p44/p42 MAP kinase, or SB203580, an inhibitor of p38 MAP kinase ... These results strongly suggest that
PGD ( 2 )
stimulates HSP27 induction through p44/p42 MAP kinase activation and p38 MAP kinase activation in osteoblasts and that PKC acts at a point upstream from both the MAP kinases
Kozawa et al., Nihon Yakurigaku Zasshi 2002
:
On the contrary, physiological regulators of bone such as endothelin-1, prostaglandin F2 alpha ( PGF2 alpha ),
PGD2 , and basic fibroblast growth factor (bFGF)
induce HSP 27 via protein kinase C ( PKC ) activation
Yoshida et al., Prostaglandins Leukot Essent Fatty Acids 2004
:
Here, we examined the effect of MTX on
PGD2 stimulated
HSP27 induction in MC3T3-E1 cells ... MTX significantly
enhanced the
PGD2- increased levels of HSP27 in a dose dependent manner, although MTX alone had no effect on the levels of
HSP27
Takai et al., Prostaglandins Leukot Essent Fatty Acids 2006
:
In the cultured MC3T3-E1 cells,
PGD ( 2 ) markedly
stimulated the phosphorylation of
HSP27 at Ser-15 and Ser-85 in a time dependent manner ... These results strongly suggest that
PGD ( 2 )
stimulates HSP27 phosphorylation via p44/p42 MAP kinase and p38 MAP kinase but not SAPK/JNK in osteoblasts
Yamauchi et al., Prostaglandins Leukot Essent Fatty Acids 2007
:
These results strongly suggest that EGCG suppresses the
PGD2 stimulated induction of
HSP27 at the point between Raf-1 and MEK1/2 in osteoblasts