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CBL — CXCL12

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: Complex of CBL-CRKL → CXCL12 (increases) Chernock et al., Blood 2001
  Evidence: In addition, SDF-1alpha stimulation enhanced the association of cbl with PI-3 kinase, Crk-L, and 14-3-3beta proteins.
• OpenBEL Selventa BEL large corpus: Complex of CBL-YWHAB → CXCL12 (increases) Chernock et al., Blood 2001
  Evidence: In addition, SDF-1alpha stimulation enhanced the association of cbl with PI-3 kinase, Crk-L, and 14-3-3beta proteins.

Text-mined interactions from Literome

Fernandis et al., Oncogene 2004 (Breast Neoplasms...) : CXCL12 induced the activation of PI 3-kinase, and increased its association with Cbl and SHP2
Okabe et al., Blood Cells Mol Dis 2006 : SDF-1alpha/CXCL12 did not induce tyrosine phosphorylation of Cbl or Cbl-b in Lck-deficient T cell line J.CaM1.6 or CD45-deficient T cell line J45.01
Lane et al., Int Immunol 2006 : The CXCL8 induced phosphorylation of Cbl was also reduced when cells were pre treated with the PI3K inhibitor LY294002