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EGF — GAST

Text-mined interactions from Literome

Chupreta et al., Am J Physiol Cell Physiol 2000 : EGF stimulates gastrin promoter through activation of Sp1 kinase activity
Bai et al., Int J Gastrointest Cancer 2002 (Adenocarcinoma...) : Originally, it was expression cloned using a DNA element mediating EGF regulation of the gastrin promoter
Bachwich et al., Mol Endocrinol 1992 : Identification of a cis-regulatory element mediating somatostatin inhibition of epidermal growth factor stimulated gastrin gene transcription ... Thus, somatostatin inhibits EGF stimulated gastrin gene transcription by a mechanism other than by interfering with cell signals elicited by the EGF receptor
Sinclair et al., Am J Physiol Gastrointest Liver Physiol 2004 : Gastrin stimulation resulted in a fivefold increase in HB-EGF-luciferase activity ... Gastrin stimulation was PKC dependent and at least partially mediated by activation of the EGF receptor
Beales et al., Life Sci 2004 : Gastrin and IL-1beta stimulated the secretion of heparin binding epidermal growth factor and amphiregulin but not transforming growth factor-alpha from parietal cells
Merchant et al., Mol Cell Biol 1991 : Consistent with this physiological role, EGF stimulates transcription of gastrin , a peptide hormone which regulates gastric acid secretion and mucosal growth ... EGF stimulation of gastrin transcription is mediated by a GC-rich gastrin EGF response element (gERE) ( GGGGCGGGGTGGGGGG ) which lies between -54 and -68 in the human gastrin promoter
Koh et al., Biochem Biophys Res Commun 1995 : Transfection studies demonstrated that the murine gastrin gene expression is stimulated by epidermal growth factor to the same extent as the human gastrin gene
Howell et al., J Cell Physiol 1995 (Colonic Neoplasms) : In the FET cells, exogenous EGF stimulates gastrin mRNA production but not in HCT 116
Watson et al., Anticancer Drugs 1994 (Pancreatic Neoplasms) : AR42J, a rat pancreatic cell line expressing receptors for both gastrin and epidermal growth factor (EGF), has been used to examine the effect of the gastrin receptor antagonist CR2093 on basal, gastrin-17 (G17) , EGF and transforming growth factor (TGF)-alpha stimulated growth in vitro
Merchant et al., J Biol Chem 1995 : We have previously shown that EGF and phorbol esters stimulate the human gastrin promoter through a novel GC-rich DNA element 5'- ( 68 ) GGGGCGGGGTGGGGGG-53 called gERE ( gastrin EGF response element )
Merchant et al., Mol Cell Biol 1996 : ZBP-89, a Krüppel-like zinc finger protein, inhibits epidermal growth factor induction of the gastrin promoter ... It binds specifically to the gastrin EGF response element and inhibits EGF induction of the gastrin promoter
Marks et al., Am J Physiol 1996 : Thus c-fos gene expression is required but is not sufficient for induction of the gastrin promoter by EGF
Konturek et al., Gut 1997 (Duodenal Ulcer...) : ( 1 ) H pylori infection in patients with duodenal ulcer was accompanied by enhanced plasma gastrin and increased mucosal content and expression of TGF alpha, EGF, and EGFr ; ( 2 ) H pylori eradication resulted in ulcer healing, reduction in plasma gastrin, and enhancement of gastric ( but not salivary ) luminal release of EGF , particularly after pentagastrin stimulation ; and ( 3 ) enhanced mucosal content and expression of TGF alpha, EGF, and EGFr and increased luminal release of EGF may contribute to ulcer healing after eradication of H pylori
Tsutsui et al., Biochem Biophys Res Commun 1997 : The present study was designed to investigate whether heparin binding epidermal growth factor-like growth factor and its related peptides are expressed in response to gastrin in rat stomach
Remington et al., Biochem Biophys Res Commun 1997 (Adenocarcinoma...) : Overexpression of this factor prevents EGF induction of the gastrin promoter ; therefore, we postulated that ZBP-89 may modulate cellular proliferation
Merchant et al., Biochem Biophys Res Commun 1999 (Adenocarcinoma...) : We have shown previously that EGF receptor activation stimulates gastrin gene expression through a GC-rich element called gERE