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RAC1 — WNT5A

Pathways - manually collected, often from reviews:

• NCI Pathway Database Noncanonical Wnt signaling pathway: RAC1/GDP complex (RAC1) → WNT5A/FZD2/ROR2(dimer)/DVL2 complex (WNT5A-FZD2-ROR2-DVL2) (modification, collaborate)
  Sato et al., EMBO J 2010
• NCI Pathway Database Noncanonical Wnt signaling pathway: WNT5A/FZD2/ROR2(dimer)/DVL2 complex (WNT5A-FZD2-ROR2-DVL2) → RAC1/GTP complex (RAC1) (modification, activates) Sato et al., EMBO J 2010

Text-mined interactions from Literome

Kurayoshi et al., Cancer Res 2006 (Neoplasm Invasiveness...) : Wnt-5a activated focal adhesion kinase and small GTP binding protein Rac , both of which are known to play a role in cell migration
Andersson et al., PloS one 2008 : We hereby report that Wnt5a activated the GTPase Rac1 in DA cells and that Rac1 inhibitors blocked the Wnt5a induced DA neuron differentiation of ventral midbrain ( VM ) precursor cultures, linking Wnt5a induced differentiation with a known effector of Wnt/PCP signaling
Sato et al., EMBO J 2010 : Wnt5a activated Rac in the beta-catenin independent pathway, and Frizzled2 (Fz2) and Ror1 or Ror2 were required for this action
Čajánek et al., Mol Cell Biol 2013 (Wnt Signaling Pathway) : Next, we show that Tiam1, a Rac1 guanosine exchange factor (GEF), is expressed in the ventral midbrain, interacts with Dvl, facilitates Dvl-Rac1 interaction, and is required for Dvl- or Wnt5a induced activation of Rac1
Zhu et al., Cell Signal 2013 (Breast Neoplasms) : Rab35 is required for Wnt5a/Dvl2 induced Rac1 activation and cell migration in MCF-7 breast cancer cells ... Dvl2 siRNA significantly decreased background and Wnt5a induced Rab35/Rac1 activation and, consequently, cell migration ... Rab35 short hairpin RNA ( shRNA ) remarkably inhibited background and Wnt5a induced Rac1 activation and cell migration