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IGF1 — PLG

Pathways - manually collected, often from reviews:

• Reactome Reaction: IGF1 → PLG (reaction) Angelloz-Nicoud et al., Growth Horm IGF Res 1998*, Booth et al., Am J Physiol Endocrinol Metab 2002, Mohan et al., J Endocrinol 2002, Firth et al., Endocr Rev 2002, Holly et al., Neuroendocrinology 2006, Lalou et al., Endocrinology 1994*, Angelloz-Nicoud et al., Endocrinology 1995*, Rajah et al., Prog Growth Factor Res 1995, Angelloz-Nicoud et al., Growth Regul 1996*, Lalou et al., Horm Res 1996*

Text-mined interactions from Literome

Hilal et al., Arthritis Rheum 1999 (Osteoarthritis) : IGF-1 also reduced plasmin activity in OA osteoblasts while it did not modify this activity in normal osteoblasts
Dunn et al., Cancer Res 2001 (Breast Neoplasms...) : Up-regulation of urokinase-type plasminogen activator by insulin-like growth factor-I depends upon phosphatidylinositol-3 kinase and mitogen activated protein kinase kinase
Miceli et al., J Clin Endocrinol Metab 2005 : Effects of insulin-like growth factor I and II on prostaglandin synthesis and plasminogen activator activity in human umbilical vein endothelial cells
Dimova et al., Thromb Haemost 2005 (MAP Kinase Signaling System...) : Transcriptional regulation of plasminogen activator inhibitor-1 expression by insulin-like growth factor-1 via MAP kinases and hypoxia-inducible factor-1 in HepG2 cells
Sorrell et al., J Biol Chem 2006 : Insulin-like growth factor binding protein-5 activates plasminogen by interaction with tissue plasminogen activator, independently of its ability to bind to plasminogen activator inhibitor-1, insulin-like growth factor-I, or heparin
Koutsilieris et al., Expert Opin Investig Drugs 2006 (Adenocarcinoma...) : Herein, the molecular evidence documenting that bone metastasis microenvironment survival factors ( mainly the paracrine growth hormone independent, urokinase-type plasminogen activator mediated increase of IGF-1 and the endocrine production of growth hormone dependent IGF-1, mainly liver derived IGF-1 production ) produce an epigenetic form of prostate cancer cells that are resistant to proapoptotic therapies is reviewed
Oh et al., Mol Cancer Ther 2006 (Lung Neoplasms...) : Antimetastatic activity of insulin-like growth factor binding protein-3 in lung cancer is mediated by insulin-like growth factor independent urokinase-type plasminogen activator inhibition
Grant et al., Curr Eye Res 1990 : Insulin-like growth factor I stimulates proliferation, migration, and plasminogen activator release by human retinal pigment epithelial cells
Martin et al., Growth Regul 1993 : Targeted and regulated production of plasmin might also contribute to the coupling of bone formation to resorption, by activating latent TGF beta in bone, and activating IGF-1 by freeing it from association with inhibitory binding protein
Tranque et al., Endocrinology 1994 : Differential regulation of astrocyte plasminogen activators by insulin-like growth factor-I and epidermal growth factor
Yoshimura et al., Biol Reprod 1996 : Effects of insulin-like growth factor-I on follicle growth, oocyte maturation, and ovarian steroidogenesis and plasminogen activator activity in the rabbit ... We examined the effects of insulin-like growth factor (IGF)-I on follicular growth, oocyte maturation, and ovarian steroidogenesis and plasminogen activator (PA) activity in vitro, using a perfused rabbit ovary preparation in order to determine whether the follicle stimulating effects of growth hormone (GH) are mediated by IGF-I