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RUNX2 — TNF

Text-mined interactions from Literome

Gilbert et al., J Biol Chem 2002 : Expression of the osteoblast differentiation factor RUNX2 ( Cbfa1/AML3/Pebp2alpha A ) is inhibited by tumor necrosis factor-alpha ... We investigated the effect of the inflammatory cytokine tumor necrosis factor alpha (TNF) on the expression of RUNX2 because TNF is known to inhibit differentiation of osteoblasts from pluripotent progenitor cells ... The effect of TNF on RUNX2 gene transcription was evaluated using a 0.6-kb RUNX2 promoter-luciferase reporter in MC3T3-E1 cells ... Our results indicate that TNF regulates RUNX2 expression at multiple levels including destabilization of mRNA and suppression of transcription
Deng et al., Zhonghua Wai Ke Za Zhi 2002 : TNF-alpha in combination with BMP-2 could induce fibroblasts to express Cbfa1 and osteocalcin mRNA
Nakayama et al., Cell Biol Int 2004 (Osteosarcoma) : We used RT-PCR to examine the effects of TNF-alpha on bone sialoprotein ( BSP ), core binding factor a1 (Cbfa1) , osterix, alpha 1 ( I ) collagen, cyclooxygenase-2 (COX-2), interleukin-6 (IL-6), cathepsin B, cathepsin L and tissue inhibitors of metalloproteinase-1 ( TIMP-1 )
Kaneki et al., J Biol Chem 2006 : Tumor necrosis factor promotes Runx2 degradation through up-regulation of Smurf1 and Smurf2 in osteoblasts
Yamashita et al., J Endocrinol 2008 (MAP Kinase Signaling System) : FPP and GGPP also restored the simvastatin effects on TNF-alpha induced suppression of Runx2 and ALP activity
Matsumoto et al., Mol Cell Endocrinol 2010 : In addition, TNF-alpha suppressed BMP-2 induced Runx2 and osteocalcin expression, and estradiol and dexamethasone reversed the TNF-alpha effects on BMP-2 induced Runx2 expression ... Of note, the inhibitory effects of TNF- on BMP-2 induced Runx2 and osteocalcin expression were reversed by SAPK/JNK inhibition regardless of the presence of estradiol
Sun et al., Eur J Pain 2012 (Chronic Disease...) : CCD induced both mechanical allodynia and thermal hyperalgesia, and increased the expression of TNF-a , IL-1ß, IL-6 and NF-?B
He et al., PloS one 2012 (Inflammation...) : TNF-a also induces the expression of E3 ubiquitin ligase protein Smurf1 and Smurf2 and promotes degradation of Runx2 , another key transcription factor regulating osteoblast differentiation and bone formation