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CTNNB1 — SKP1
Pathways - manually collected, often from reviews:
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
SCF complex (BTRC-SKP1-CUL1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TCF4/beta catenin complex (TCF7L2-CTNNB1)
→
TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
TRRAP (TRRAP)
→
TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Regulation of nuclear beta catenin signaling and target gene transcription:
SCF complex (BTRC-SKP1-CUL1)
→
TCF4/beta catenin/TRRAP/SCF complex (TCF7L2-CTNNB1-TRRAP-BTRC-CUL1-SKP1)
(modification, collaborate)
Finkbeiner et al., Cell cycle (Georgetown, Tex.) 2008
Evidence: physical interaction
-
NCI Pathway Database Degradation of beta catenin:
SCF complex (BTRC-SKP1-CUL1)
→
APC/beta catenin complex (APC-CTNNB1)
(modification, activates)
Hart et al., Curr Biol 1999, Kitagawa et al., EMBO J 1999, Winer et al., J Biol Chem 2006, Seo et al., Cell Signal 2009, Su et al., Mol Cell 2008
Evidence: assay, physical interaction
-
Reactome Reaction:
CTNNB1
→
SKP1
(reaction)
Latres et al., Oncogene 1999, Winston et al., Genes Dev 1999
-
Reactome Reaction:
CTNNB1
→
SKP1
(indirect_complex)
Latres et al., Oncogene 1999, Winston et al., Genes Dev 1999
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
CTNNB1
—
SKP1
(physical association, affinity chromatography technology)
Wang et al., Cancer Sci 2011*
-
IRef Biogrid Interaction:
CTNNB1
—
SKP1
(physical association, affinity chromatography technology)
Matsuzawa et al., Mol Cell 2001
-
IRef Biogrid Interaction:
CTNNB1
—
SKP1
(direct interaction, enzymatic study)
Dimitrova et al., J Biol Chem 2010*
-
IRef Biogrid Interaction:
CTNNB1
—
SKP1
(direct interaction, unspecified method)
Winston et al., Genes Dev 1999
-
IRef Hprd Interaction:
Complex of BTRC-BTRC-SKP1-CTNNB1-SKP1-CTNNB1-BTRC-SKP1-CTNNB1
(in vivo)
Wu et al., Mol Cell 2003
-
IRef Intact Interaction:
Complex of RBX1-BTRC-CUL1-UBE2D2-CTNNB1-UBA1-SKP1
(ubiquitination reaction, enzymatic study)
Duda et al., Cell 2008
-
IRef Intact Interaction:
Complex of BTRC-CTNNB1-SKP1
(physical association, x-ray crystallography)
Wu et al., Mol Cell 2003
Text-mined interactions from Literome
Angers et al., Nat Cell Biol 2006
:
Considered with evidence that the distinct Cullin-1 based
SCF(beta-TrCP)complex regulates
beta-catenin stability, our data on the stability of Dishevelled demonstrates that two distinct ubiquitin ligase complexes regulate the Wnt-beta-catenin pathway
Megy et al., FEBS Lett 2006
(Neoplasms) :
Phosphorylation of
beta-Catenin at sites Ser33 and Ser37 on the DSGXXS motif is
required for the interaction of beta-Catenin with the ubiquitin ligase
SCF(beta-TrCP)