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AKT1S1 — TSC2

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Intact Interaction: Complex of 78 proteins (association, tandem affinity purification) Gloeckner et al., Proteomics 2007
• IRef Intact Interaction: Complex of 26 proteins (association, anti tag coimmunoprecipitation)
• IRef Intact Interaction: Complex of YWHAH-KLC3-PARD3-YWHAH-MARK2-YWHAZ-AKT1S1-KLC2-TSC2 (association, tandem affinity purification) Gloeckner et al., Proteomics 2007

Text-mined interactions from Literome

Hayashi et al., Am J Physiol Endocrinol Metab 2007 : Consistent with this, GH increased the phosphorylation of TSC2 , an upstream regulator of mTORC1 , at sites that are targets for Akt/PKB
Mills et al., Proc Natl Acad Sci U S A 2008 (Lymphoma) : Here, we demonstrate that loss of TSC2 in the E mu-myc murine lymphoma model leads to mTORC1 activation and accelerated oncogenesis caused by a defective apoptotic program despite compromised AKT phosphorylation
Wolff et al., Mol Cell Biol 2011 (Anoxia) : We previously reported that mTORC1 regulation by hypoxia involves Redd1 and the Tsc1/Tsc2 complex