Lunghi et al., Leukemia 2005
(Leukemia, Promyelocytic, Acute) :
MEK1 inhibitors dephosphorylated Bad and inhibited the ATO induced increase of Bcl-xL , overcoming ATO resistance in NB4-As ( R )
Nakamura et al., J Biol Chem 2006
(MAP Kinase Signaling System) :
We found that MNSFbeta.Bcl-G directly bound to ERKs and inhibited ERK activation by MEK1 Ren et al., J Biol Chem 2007
(Leukemia, Myeloid...) :
Shp2E76K induced Bcl-XL expression was suppressed by Mek inhibitors and by a dominant negative Mek1 mutant but not by the phosphoinositide 3-phosphate inhibitor LY294002 and the Akt inhibitor API-2
Brinkkoetter et al., J Clin Invest 2009
(Glomerulonephritis) :
Furthermore, we found that levels of phosphorylated MEK1/2 and ERK1/2 were decreased in cyclin I-deficient podocytes and that inhibition of MEK1/2 restored Bcl2 and Bcl-XL protein levels