◀ Back to CASP7
CASP7 — RIPK3
Text-mined interactions from Literome
Gentle et al., J Biol Chem 2011
:
After receptor ligation,
RIPK1 not only modulates activation of both canonical and NIK dependent NF-?B, but also
regulates caspase-8 activation and cell death
Duprez et al., Immunity 2011
(Cecal Diseases...) :
An additional switch decides, depending on the cellular context, between
caspase dependent apoptosis and
RIP kinase ( RIPK ) -mediated necrosis, also termed necroptosis
Dillon et al., Cell reports 2012
(Necrosis) :
This can be explained by the convergence of two cell processes : the enzymatic activity of the
FADD-caspase-8-cFLIPL complex blocks
RIPK3 dependent signaling ( including necrosis ), whereas cFLIPL blocks RIPK3 independent apoptosis promoted by the FADD-caspase-8 complex
Kaczmarek et al., Immunity 2013
(Bacterial Infections...) :
Regulated necrosis, termed necroptosis, is negatively regulated by
caspase-8 and is
dependent on the kinase activity of RIPK1 and
RIPK3
Dondelinger et al., Cell Death Differ 2013
:
In both TNF induced RIPK1 kinase dependent apoptotic models, we found that
RIPK3 contributes to full
caspase-8 activation independently of its kinase activity or intact RHIM domain