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MYC — WNT6
Text-mined interactions from Literome
Cowling et al., Cell cycle (Georgetown, Tex.) 2007
(Breast Neoplasms) :
Turning the tables :
Myc activates
Wnt in breast cancer
Momota et al., Oncogene 2008
(Disease Models, Animal...) :
As elevated
c-Myc expression,
activation of
Wnt/beta-catenin signaling and dysfunction of p53 are seen in human PNETs, we investigated what role these abnormalities have in the formation of PNETs
Su et al., Carcinogenesis 2009
:
Gen inhibition of
Wnt induced
c-Myc expression was mimicked by an estrogen receptor (ER)-beta-specific but not ER-alpha-specific agonist and was attenuated with loss of ER-beta expression, concordant with decreased E-cadherin expression ... E-cadherin small interfering RNA targeting eliminated Gen inhibition of
Wnt stimulated
c-Myc expression and promoted Gen induction of basal c-Myc transcript levels and subsequent proliferation
Athineos et al., Oncogene 2010
:
Crucially, the levels of Myc are twofold higher than wild-type levels showing that the level of
Myc induced by
Wnt signalling is absolutely vital for the fate of APC-deficient cells
Hsieh et al., Cancer Lett 2011
(Carcinoma, Hepatocellular...) :
We show that
Wnt inhibitors curcumin and quercetin target downstream ß-catenin activity and effectively
repress HBx mediated regulation of
c-MYC and E-cadherin
Katoh et al., Curr Pharm Biotechnol 2011
:
Canonical
WNT signaling activation
leads to transcriptional up-regulation of FGF ligand, Notch ligand, non-canonical WNT ligand, WNT antagonist, TGFß antagonist, and
MYC
Zhou et al., Biochim Biophys Acta 2012
(Wnt Signaling Pathway) :
In this study, we found the AICD to strongly inhibit Wnt induced transcriptional reporter activity, and to counteract
Wnt induced
c-Myc expression
Sanchez-Ripoll et al., PloS one 2013
:
Inhibition of glycogen synthase kinase 3 ( Gsk-3 ) has been implicated in the maintenance of mouse ESC pluripotency, although there is contradictory data on its role, with enhancement of cell survival and metabolism, stabilisation of
c-Myc and
activation of
Wnt signalling proposed as potential mechanisms
Vadlakonda et al., Frontiers in oncology 2013
:
Cyclin D1 and the
c-Myc are
activated by the
Wnt signaling