Gene interactions and pathways from curated databases and text-mining

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ITPR2 — PRKACB

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

  • STRING interaction: PRKACB — ITPR2 (interaction, mapped from kegg_pathways)
  • STRING interaction: ITPR2 — PRKACB (interaction, mapped from kegg_pathways)

Text-mined interactions from Literome

Regimbald-Dumas et al., J Cell Biochem 2007 : The purpose of this study was to investigate the effect of cAMP dependent protein kinase (PKA) on the activity of IP(3)R-2 in AR4-2J cells ... Our results are consistent with an enhancing effect of PKA on IP(3)R-2 activity
Matsumoto et al., Cell Res 2012 (Calcium Signaling) : A recent report in Nature showed that PKA dependent phosphorylation of the inositol-1,4,5-trisphosphate receptor ( InsP3R ) induces Ca mobilization, leading to increase in the phosphatase activity of calcineurin and the subsequent dephosphorylation of CRTC2, thereby resulting in the induction of gluconeogenic gene expression