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NFKB1 — SULT1A1
Text-mined interactions from Literome
Lee et al., J Virol 1999
(Cell Transformation, Viral) :
Mutational analysis also revealed that
STP-C488 induced
NF-kappaB activation that was correlated with its ability to associate with TRAFs
Garcia et al., J Virol 2007
:
The amino-terminal and central proline-rich motifs of STP-A were responsible for TRAF6 and TRAF2 interactions, respectively, and STP-A and TRAF6 interaction contributed to the majority of NF-kappaB activation, whereas
STP-A and TRAF2 interaction
played a minor role in
NF-kappaB activation
Chung et al., J Biochem Mol Biol 2007
:
However, the detailed mechanism of
STP-C mediated
NF-kappaB activation has not been reported yet ...
NF-kappaB activation by
STP-C through the ubiquitinated TRAF6 causes the increased production of IL-8, an inflammatory chemokine and the enhanced expression of costimulatory molecule ICAM, which might ultimately contribute cellular transformation by the exposure of HVS infected cells with inflammatory microenvironment and chronic activation