Gene interactions and pathways from curated databases and text-mining

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NFKB1 — SULT1A1

Text-mined interactions from Literome

Lee et al., J Virol 1999 (Cell Transformation, Viral) : Mutational analysis also revealed that STP-C488 induced NF-kappaB activation that was correlated with its ability to associate with TRAFs
Garcia et al., J Virol 2007 : The amino-terminal and central proline-rich motifs of STP-A were responsible for TRAF6 and TRAF2 interactions, respectively, and STP-A and TRAF6 interaction contributed to the majority of NF-kappaB activation, whereas STP-A and TRAF2 interaction played a minor role in NF-kappaB activation
Chung et al., J Biochem Mol Biol 2007 : However, the detailed mechanism of STP-C mediated NF-kappaB activation has not been reported yet ... NF-kappaB activation by STP-C through the ubiquitinated TRAF6 causes the increased production of IL-8, an inflammatory chemokine and the enhanced expression of costimulatory molecule ICAM, which might ultimately contribute cellular transformation by the exposure of HVS infected cells with inflammatory microenvironment and chronic activation