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PRL — WAS

Text-mined interactions from Literome

Rodríguez de Fonseca et al., Brain Res 1999 : Effects of delta9-THC on VIP induced prolactin secretion in anterior pituitary cultures : evidence for the presence of functional cannabinoid CB1 receptors in pituitary cells ... In the present study the possible direct effect of the cannabinoid receptor agonist delta9-Tetrahydrocannabinol (THC) on prolactin secretion and cAMP accumulation was examined in anterior pituitary cultures ... THC ( 0.1 and 1 microM ) increased cAMP levels, and induced PRL release ( 1 and 10 mu ) ... However, THC did prevent VIP dependent increases in prolactin secretion
Rodríguez De Fonseca et al., Pharmacol Biochem Behav 1992 : This inhibitory effect of THC on PRL release was accompanied by a decreased DOPAC/DA ratio in medial basal hypothalamus that, in turn, may be a result of the fall in PRL levels rather than a direct action of the drug
Murphy et al., Pharmacol Biochem Behav 1991 : Whereas THC ( 1 microM ) alone had no effect on prolactin levels when compared to controls, THC completely prevented the E-induced increase in media prolactin levels
Steger et al., Neuroendocrinology 1983 : Interactions of delta 9-tetrahydrocannabinol (THC) with hypothalamic neurotransmitters controlling luteinizing hormone and prolactin release ... THC had no effect on basal LH levels, but it inhibited basal PRL levels and blocked the surges of both LH and PRL
Steger et al., Fertil Steril 1981 : THC ( 10 mg/kg ) attenuated serum LH and prolactin levels
Hughes et al., Endocrinology 1981 : The effects of ( -- ) trans-delta 9-tetrahydrocannabinol (THC) on tonic PRL secretion were investigated in long term ovariectomized or hypophysectomized/pituitary autografted female rats and in flask incubations of anterior pituitary tissue
Kumar et al., Subst Alcohol Actions Misuse 1983 : These results suggest that the inhibitory effects of delta 9-THC on serum LH and the stimulatory effect of the cannabinoid on Prl are mediated by an opioid mechanism
Bromley et al., Endocr Res Commun 1978 : To study effects of delta-9-tetrahydrocannabinol (THC) on the regulation of prolactin (PRL) release, a chronic cannula was placed in the right atrium of postpartum lactating rats ... These findings indicate that THC inhibits suckling induced PRL release in the postpartum rat
Fernández-Ruiz et al., Biochem Pharmacol 1997 : Interestingly, the time course of the effect of delta9-THC resembled that of AEA and AM356 only during the later part of the response, because delta9-THC produced a marked increase in plasma PRL levels at 20 min, no changes at 40 min and a decrease from 60 min up to 180 min