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FOXQ1 — SLC22A3

Text-mined interactions from Literome

Qiao et al., Cancer Res 2011 (Breast Neoplasms...) : In this study, we defined a critical functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in breast cancer cells ... Mechanistic investigations revealed that FOXQ1 induced EMT was associated with transcriptional inactivation of the epithelial regulator E-cadherin ( CDH1 ) ... Our findings define a key role for FOXQ1 in regulating EMT and aggressiveness in human cancer
Zhu et al., Int J Oncol 2013 (Carcinoma, Transitional Cell...) : In this study, we defined a pivotal functional role for the Forkhead transcription factor FOXQ1 in regulating EMT in bladder cancer ... In conclusion that FOXQ1 may be a novel EMT inducing transcription factor through controlling the expression of E-cadherin and aggressiveness of cancer cells and targeting the transcription factor FOXQ1 could hence serve as a novel therapeutic strategy for cancer patients