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FGF9 — PCSK1
Text-mined interactions from Literome
Hatch et al., Orthod Craniofac Res 2007
(Craniosynostoses) :
Towards this goal we have constructed a PC-1 gene promoter/firefly luciferase reporter construct, in order to more directly investigate the
regulation of
PC-1 by
FGF/FGFR signaling in osteoblastic and non-osteoblastic cells ... Preliminary results confirm that
FGF/FGFR signaling, either via treatment with FGF2 or via expression of a Crouzon syndrome associated mutant FGFR2,
induces PC-1 promoter activity in osteoblastic cells in culture
Hatch et al., J Bone Miner Res 2009
:
Specifically,
FGF2 was unable to
induce PC-1 expression in Runx2 negative nonbone cells or in calvarial cells from Runx2-deficient mice