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CDH1 — EZH2
Text-mined interactions from Literome
Cao et al., Oncogene 2008
(Breast Neoplasms...) :
Repression of
E-cadherin by the polycomb group protein
EZH2 in cancer ... Here, we demonstrate that
EZH2 mediates transcriptional silencing of the tumor suppressor gene
E-cadherin by trimethylation of H3 lysine 27 ... Histone deacetylase inhibitors can prevent
EZH2 mediated repression of
E-cadherin and attenuate cell invasion, suggesting a possible mechanism that may be useful for the development of therapeutic treatments
Yamaguchi et al., Cancer Sci 2010
(Gallbladder Neoplasms) :
In TGBC2TKB cells, the expression of
EZH2 and HDAC1/2 were decreased by SAHA treatment, and p16(INK4a),
E-cadherin , and p21were simultaneously
activated ; however, no such findings were obtained in HGECs, suggesting that the effect of SAHA depends on the EZH2 mediated tumor suppressor loss ... In TGBC2TKB cells, the expression of
EZH2 and HDAC1/2 were decreased by SAHA treatment, and p16(INK4a),
E-cadherin , and p21were simultaneously
activated ; however, no such findings were obtained in HGECs, suggesting that the effect of SAHA depends on the EZH2 mediated tumor suppressor loss
Wang et al., Mol Carcinog 2013
(Carcinoma, Squamous Cell...) :
These observations were confirmed in vitro, in which knockdown of
EZH2 induced
E-cadherin expression and reduced cell migration and invasion ... In contrast, ectopic transfection of
EZH2 led to reduced
E-cadherin expression and enhanced cell migration and invasion
Xia et al., PloS one 2012
(Carcinoma, Hepatocellular...) :
Silencing
EZH2 or CTNNB1 expression suppressed the growth and invasion of HCC cells and
induced E-cadherin ( CDH1 ), known to inhibit cell invasion and metastasis