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HIF1A — IL1A

Text-mined interactions from Literome

Stiehl et al., FEBS Lett 2002 : We investigated whether inhibitors of mitogen activated protein kinase kinases ( MAPKKs : PD 98059, U0126 ) and phosphatidylinositol 3-kinase ( PI3K : LY 294002 ) do not only lower the hypoxia induced, but also the insulin- and IL-1 induced HIF-1alpha accumulation and HIF-1 DNA binding in human hepatoma cell cultures ( line HepG2 )
Haddad et al., Eur Cytokine Netw 2002 : Furthermore, evidence that reactive oxygen species ( ROS ) signaling mediates interleukin (IL)-1 beta dependent regulation of HIF-1 alpha has yet to be ascertained in alveolar epithelial cells ... The antioxidants, dimethyl sulfoxide ( DMSO ) and 1,3-dimethyl-2-thiourea ( DMTU ), purported to be prototypical scavengers of H2O2 and *OH, attenuated, in a dose dependent manner, IL-1 beta induced HIF-1 alpha nuclear translocation and activation
Jung et al., FASEB J 2003 (Inflammation...) : Interestingly, although this pathway is stimulated by upstream signaling via AKT and mTOR and requires new transcription, IL-1 mediated HIF-1alpha induction also utilizes a post-transcriptional mechanism that involves antagonism of VHL dependent HIF-1alpha degradation, which results in increased HIF-1alpha protein stability ... Although COX-2 inhibitors attenuated IL-1 mediated HIF-1alpha induction, prostaglandin E2 ( PGE2 ), a physiological product of COX-2, induced HIF-1alpha protein in a dose dependent manner
Murata et al., J Orthop Res 2006 (Anoxia...) : Both hypoxia and IL-1 induced HIF-1alpha were attenuated by p38 MAPK and JNK inhibitors
Zhu et al., Osteoarthritis Cartilage 2009 : Additionally, IL-1beta stimulated both HIF-1alpha and PAI-1 in articular chondrocytes, and the IL-1beta mediated induction of PAI-1 was inhibited partly by HIF-1alpha silencing