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JUN — MMP13
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
Text-mined interactions from Literome
Westermarck et al., FASEB J 1999
(Neoplasm Invasiveness...) :
This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the
role of mitogen activated protein kinases and
AP-1 and ETS transcription factors in the regulation of
MMP gene expression during invasion process
Mengshol et al., Arthritis Rheum 2000
(MAP Kinase Signaling System) :
We found that IL-1 induction of
MMP-13 requires p38 activity,
c-Jun N-terminal kinase (JNK) activity and NF-kappaB translocation
Onodera et al., J Biol Chem 2002
:
Similarly, a selective mitogen activated protein kinase ( MAPK ) kinase ( MEK)1/2 inhibitor ( PD98059 ) and
c-jun/activator protein (AP)-1 inhibitor ( curcumin )
suppressed MMP-13 mRNA up-regulation induced by MIF
Sato et al., Cancer Res 2002
(Fibrosarcoma...) :
These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells, and that the nobiletin mediated inhibition of
activator protein-1 binding activity is at least partly
involved in the suppression of
MMP expression
Liacini et al., Exp Cell Res 2003
:
Induction of
matrix metalloproteinase-13 gene expression by TNF-alpha is
mediated by MAP kinases,
AP-1 , and NF-kappaB transcription factors in articular chondrocytes
Zeliadt et al., Biochem Biophys Res Commun 2004
:
MMP-13 promoter studies indicated that TPA
requires AP-1 , but not Runx, to induce
MMP-13 gene expression
Chu et al., Oncogene 2007
(Carcinoma, Basal Cell...) :
The transcriptional regulation of
MMP-13 by SDF-1alpha was
mediated by phosphorylation of extracellular signal related kinase 1/2 and activation of the AP-1 component
c-Jun
Kajanne et al., J Cell Physiol 2007
:
Here we provide genetic and biochemical evidence that EGF-R- and
AP-1 mediated signals are
required for
MMP expression and collagen contraction in fibroblasts
Hammaker et al., Arthritis Res Ther 2007
(Arthritis, Rheumatoid) :
c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (
MMP ) gene expression and joint destruction in inflammatory arthritis
Oliver et al., J Rheumatol 2007
(Arthritis, Experimental...) :
We evaluated whether a vanadium
AP-1 inhibitor could
reduce MMP expression and subsequent joint damage in CIA
Tan et al., Carcinogenesis 2008
(Carcinoma, Squamous Cell...) :
CXCL12 seems to enhance LHSCC cell invasion through paracrine activated CXCR4, which triggers
ERK/c-Jun dependent
MMP-13 upregulation
Lu et al., J Cell Physiol 2009
:
These results suggest that hypoxia induced
MMP-13 expression in astrocytes is
regulated by c-Fos and
c-Jun
Pradeepkumar Singh et al., J Pineal Res 2011
(Diabetes Mellitus, Experimental...) :
Moreover, increased expression of both
MMP-1 and -13 was
mediated by
activator protein-1 activation via extracellular signal regulated kinase 1/2 which were parallel to upregulation of tumor necrosis factor-a, interleukin-1ß, and heat shock protein-70 during ulceration
Chan et al., International journal of molecular sciences 2011
:
In the current study, pretreatment with nitric oxide ( NO ) scavengers inhibited PDT induced mitochondrial
membrane potential ( MMP ) changes,
activation of caspase-9, caspase-3, p21 activated protein kinase 2 (PAK2) and
c-Jun N-terminal kinase (JNK) , and gene expression of p53 and p21 involved in apoptotic signaling
Lee et al., J Dermatol Sci 2013
:
In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent
activation of mitogen activated protein kinase ( MAPK ), ATF-2, and
c-Jun , and
MMP expression