Gene interactions and pathways from curated databases and text-mining

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STAT1 — STAT2

Pathways - manually collected, often from reviews:

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

Text-mined interactions from Literome

Usacheva et al., J Biol Chem 2001 : Disruption of the IFNalpha receptor-RACK1 interaction abolishes not only IFNalpha induced tyrosine phosphorylation of STAT1 but also activation of STAT2 , indicating that RACK1 plays a central role in early signaling through the Jak-STAT pathway
Parisien et al., J Virol 2002 : While type II human parainfluenza virus induces STAT2 degradation, simian virus 5 induces STAT1 degradation
Andrejeva et al., J Virol 2002 (Xeroderma Pigmentosum) : Evidence is also presented which demonstrates that STAT2 is required for the degradation of STAT1 by SV5
Gotoh et al., J Virol 2003 : Furthermore, expression of STAT1 enhanced the inhibitory effect of the C protein on STAT2 activation in U3A cells
Radaeva et al., Biochem J 2004 (Carcinoma, Hepatocellular...) : Overexpression of STAT1 via stable transfection enhances IFN-gamma activation of STAT1, but surprisingly attenuates IFN-alpha activation of STAT1, STAT2 and STAT3 without affecting Janus kinase activation ... This STAT1 mediated inhibition does not require STAT1 tyrosine phosphorylation because overexpression of dominant negative STAT1 with a mutation on tyrosine residue 701 also blocks IFN-alpha activation of STAT1, STAT2 and STAT3
Ramaswamy et al., Am J Respir Cell Mol Biol 2004 (Respiratory Syncytial Virus Infections) : Furthermore, nonspecific pharmacologic inhibition of proteasome function in RSV infected cells restored Stat2 levels and IFN dependent activation of Stat1
Precious et al., J Gen Virol 2005 : As previously reported, STAT1 could not be detected in human cells that expressed SV5 V protein constitutively, whilst STAT2 could not be detected in human cells that expressed hPIV2 V protein, although the levels of STAT1 may also have been reduced in some human cells infected with hPIV2 ... In contrast, STAT1 could not be detected , whereas STAT2 remained present, in a variety of animal cells, including canine ( MDCK ) cells, that expressed the V protein of either SV5 or hPIV2
Dimberg et al., Scand J Immunol 2006 : Taken together, our data suggest that ATRA induced regulation of Stat2 , ICSBP and C/EBPepsilon is dependent on active Stat1 , and that a failure to correctly regulate these transcription factors is associated with the inhibition of monocytic differentiation
Jia et al., PloS one 2010 : H5N1 NS1 reduces IFN-inducible tyrosine phosphorylation of STAT1 , STAT2 and STAT3 and inhibits the nuclear translocation of phospho-STAT2 and the formation of IFN-inducible STAT1 : 1-, STAT1 : 3- and STAT3 : 3- DNA complexes
Mowen et al., J Biol Chem 1998 : Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1