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ALOX5 — IL13

Text-mined interactions from Literome

Vargaftig et al., Am J Respir Cell Mol Biol 2003 (Bronchial Hyperreactivity...) : To investigate the potential role of leukotrienes ( LT ) in mediating these effects, we studied the ability of IL-13 to induce the expression of 5-lipoxygenase (5-LO) , we compared the effects of IL-13 and of various leukotrienes on different biological parameters and the interference by the 5-LO inhibitor zileuton ( orally, 50 mg/kg, 3 times a day for 3 days ), and by some antagonists
Shim et al., J Immunol 2006 (Chronic Disease...) : Lastly, mechanistic insights are provided by demonstrating that IL-13 induced 5-LO activation is required for optimal stimulation and activation of TGF-beta(1) and the inhibition of matrix metalloproteinase-12
Rainsford et al., J Pharm Pharmacol 1996 : Effects of 5-lipoxygenase inhibitors on interleukin production by human synovial tissues in organ culture : comparison with interleukin-1-synthesis inhibitors