Ludwig et al., Thromb Haemost 2007
(Vasculitis) :
Transmembrane CX3CL1 and CXCL16 are constitutively shed from the cell surface by the activity of a disintegrin and metalloproteinase ( ADAM) 10, and cleavage can be rapidly enhanced by activation of the closely related enzyme ADAM17 Uchida et al., Lab Invest 2013
(MAP Kinase Signaling System...) :
CX3CL1 release was suppressed by specific inhibitors of ERK, MMP, and ADAM , and ERK was associated with CX3CL1 transcription