Carter et al., J Biol Chem 2004
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We propose that this reflects polyubiquitin dependent sorting of Met, as the overexpression of ubiquitin but not K48R ubiquitin also restores hepatocyte growth factor dependent phosphorylation of the endosomal coat protein Hrs from inhibition by lactacystin
Row et al., Biochem J 2005
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Consistent with this, expression of a dominant negative form of the E3 ubiquitin ligase, c-Cbl, inhibits EGF- and HGF dependent Hrs phosphorylation