Iwasaki et al., Eur J Immunol 2013
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Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4 ( + ) T cells ... We previously showed that forced expression of early growth response gene 2 (Egr-2) , a transcription factor required for T-cell anergy induction, induces IL-10 and lymphocyte activation gene 3 expression and confers regulatory activity on CD4 ( + ) T cells in vivo ... Here, we evaluated the role of Egr-2 in IL-27 induced IL-10 production
Iwasaki et al., Nihon Rinsho Meneki Gakkai Kaishi 2013
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We found that the expression level of Egr-2 , a transcription factor required for T cell anergy induction, is elevated in LAG3 Treg and that forced expression of Egr-2 induces LAG-3 expression and IL-10 production