◀ Back to PCNA
PCNA — RBL2
Text-mined interactions from Literome
Howard et al., Cancer Res 2000
:
Here we found that induction of
pRb2/p130 in vivo specifically
inhibits cyclin A- and
cyclin E-associated kinase activity and by doing so induces p27Kip1 levels presumably by inhibiting p27Kip1 targeted proteolysis by cyclin E-Cdk2 phosphorylation of p27Kip1
Carroll et al., J Biol Chem 2000
(Breast Neoplasms) :
A pure estrogen antagonist inhibits
cyclin E-Cdk2 activity in MCF-7 breast cancer cells and
induces accumulation of
p130-E2F4 complexes characteristic of quiescence
Harvat et al., J Invest Dermatol 2001
(Carcinoma, Squamous Cell) :
The interferon-gamma induced irreversible growth arrest state is characterized by inhibition of
cyclin dependent kinases, prevention of Rb and
p130 ( Rb2 ) phosphorylation, and increases in p27 ( Kip1 ), p16(Ink4a), and p130 proteins, together with a transient increase in p21 ( Waf1/Cip1 )
Poplawski et al., Thyroid research 2008
:
p107 and
p130 inhibits activity of
cyclin/cdk2 complexes