Gene interactions and pathways from curated databases and text-mining

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PSEN2 — TP53

Text-mined interactions from Literome

Li et al., Int J Radiat Oncol Biol Phys 1999 (Nasopharyngeal Neoplasms) : XRT alone stimulated minimal p53 expression in control cells ; Ad5CMV-p53 alone induced significant recombinant p53 expression, which was not further enhanced by the addition of XRT
Nguyen et al., Biochem Biophys Res Commun 2007 (Alzheimer Disease) : Mutant presenilin 2 increased oxidative stress and p53 expression in neuronal cells ... These findings indicated that mutant presenilin 2 clearly increases oxidative stress and p53 expression, which could be implicated in promoting mutant presenilin 2-induced neurodegeneration in Alzheimer 's disease, and the influence of mutant presenilin 2 in Alzheimer 's disease may be brain regional and age related effects
Lipponen et al., J Pathol 1994 (Carcinoma, Transitional Cell...) : DNA ploidy, S-phase fraction, mitotic index, morphometric nuclear features, and expression of c-erbB-2, p53 , and epidermal growth factor receptor were independent of expression of pS2