Xu et al., J Clin Endocrinol Metab 2004
(Ovarian Neoplasms) :
These findings demonstrate that Nodal induces apoptosis and inhibits proliferation via ALK7 and Smad2/3 and that the effect of Nodal-ALK7 on apoptosis may be mediated in part by the down-regulation of Xiap and activation of caspase-9 and caspase-3
Xu et al., Mol Cancer Res 2006
(Carcinoma...) :
ALK7-ca induced the expression of proapoptotic factor Bax but suppressed the expression of antiapoptotic factors Bcl-2, Bcl-XL, and Xiap Wang et al., Mol Endocrinol 2006
:
Dominant negative Smad2 significantly attenuated ALK7-ca induced down-regulation of Xiap and thus rescued granulosa cells from undergoing apoptosis