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CREB3 — LPA
Text-mined interactions from Literome
Lee et al., Biochem Biophys Res Commun 2003
(MAP Kinase Signaling System) :
We found that
LPA rapidly
stimulated phosphorylation of
CREB at Ser133 in a time- and dose dependent manner, as revealed by immunoblot analysis with a phospho-specific antibody recognizing CREB on Ser133 ...
LPA induced phosphorylation of
CREB was dependent on the activation of extracellular signal regulated kinase 1/2 ( ERK1/2 ) and p38 mitogen activated protein kinase ( p38 MAPK ) ... Inhibition of ERK1/2 with PD98059 and of p38 MAPK with SB203580 efficiently blocked
LPA mediated phosphorylation of
CREB ... The
LPA induced
CREB phosphorylation was abolished by H89, an inhibitor of mitogen- and stress activated protein kinase-1 ( MSK1 ) ... Together, these data suggest that
LPA stimulates nuclear transcription factor
CREB via mitogen activated protein kinase signaling components, ERK1/2, p38 MAPK, and MSK1 in Rat-2 fibroblast cells
Cechin et al., Neurochem Res 2005
(Glioma) :
LPA induced transient ( 10 min ) phosphorylations of ERK 1/2, Akt and the transcription factor
CREB ... The
LPA induced phosphorylation of ERK 1/2 and
CREB was blocked by inhibition of PI3K, PKC and MEK, but that of Akt was only inhibited by wortmannin, the PI3K inhibitor ... Inhibition of Rho kinase or NHE1 did not reduce the
LPA induced phosphorylation of ERK, Akt or
CREB
Rhee et al., Neuroreport 2006
:
Moreover,
LPA stimulated
CREB phosphorylation, which was inhibited by not only H89 but also Rp-cAMP
Jang et al., Exp Mol Med 2006
:
However, LPA dependent slope of luciferase increased more rapidly in senescent cells than in young cells, presumably due to an increase of
LPA induced
CREB phosphorylation
Lee et al., J Cell Biochem 2008
(MAP Kinase Signaling System) :
Recently, we reported that
LPA stimulates cAMP response element binding protein (
CREB ) through mitogen- and stress activated protein kinase-1 ( MSK1 ) ... To investigate the
CREB mediated c-fos activation by
LPA , various c-fos promoter-reporter constructs containing wild-type and mutated SRE and CRE were tested for their inducibility by LPA in transient transfection assays ... Chromatin immunoprecipitation assay revealed that
LPA induced an increased binding of phosphorylated
CREB and CREB binding protein (CBP) to the CRE region of the endogenous c-fos promoter
Kwon et al., Biochem Biophys Res Commun 2009
:
Moreover, levels of c-fos mRNA and cyclin D1 protein were increased via
LPA induced
CREB phosphorylation
Kim et al., Mol Cells 2012
(Carcinoma, Embryonal...) :
LPA induced phosphorylation of
CREB was efficiently blocked by U0126 and H89, inhibitors of the MAP kinases ERK1/2 and mitogen- and stress activated protein kinase 1, respectively