Maillet et al., Nat Cell Biol 2003
(Alzheimer Disease) :
We also show that Rac activation results from activation of Rap1 through the cAMP guanine nucleotide-exchange factor (GEF) Epac1 Birukova et al., Exp Cell Res 2007
(Respiratory Distress Syndrome, Adult) :
Prostaglandins PGE ( 2 ) and PGI ( 2 ) promote endothelial barrier enhancement via PKA- and Epac1/Rap1 dependent Rac activation