◀ Back to RAC1
DOCK3 — RAC1
Text-mined interactions from Literome
Namekata et al., Proc Natl Acad Sci U S A 2010
:
Brain derived neurotrophic factor (BDNF)-TrkB signaling recruits the Dock3/WAVE1 complex to the plasma membrane, whereupon
Dock3 activates
Rac and dissociates from the WAVE complex in a phosphorylation dependent manner ... BDNF induces axonal sprouting through
Dock dependent
Rac activation, and adult transgenic mice overexpressing Dock3 exhibit enhanced optic nerve regeneration after injury without affecting WAVE expression levels
Kulkarni et al., J Biol Chem 2011
:
Multiple factors confer specific Cdc42 and
Rac protein
activation by
dedicator of cytokinesis ( DOCK ) nucleotide exchange factors
Ladhani et al., Neoplasia (New York, N.Y.) 2011
(Neoplasm Invasiveness...) :
These changes in cell shape depended on decreased RhoA and increased
Rac1 activation and were
mediated by the up-regulation of Rac1-GEF,
DOCK3 and down-regulation of Rac1-GAP, ARHGAP22
Kiyokawa et al., Genes Dev 1998
:
Activation of
Rac1 by a Crk SH3 binding protein,
DOCK180