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HBEGF — MMP2
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Shah et al., Mol Endocrinol 2004
:
These data demonstrate that the individual actions of Ang II on EGF-R transactivation in specific cell types are related to differential involvement of
MMP dependent
HB-EGF release
Zhou et al., Am J Physiol Heart Circ Physiol 2007
:
Inhibition of
heparin binding EGF-like growth factor ( HB-EGF ) release by CRM-197 and
inhibition of
matrix metalloproteinases ( MMP ) by GM-6001 abolished PAF induced MAP kinase activation and cell proliferation
Yagi et al., Mol Cancer Ther 2008
(Neoplasm Invasiveness...) :
The reduction of
HB-EGF expression
attenuated the chemotactic invasive ability and the expression of
matrix metalloprotease (MMP)-2 and vascular endothelial growth factor ( VEGF ), leading to the inhibition of cell invasion and angiogenesis
Ogunwobi et al., Br J Biomed Sci 2008
(Adenocarcinoma...) :
Leptin increased extracellular release of
HB-EGF and TGFalpha and this was
blocked by
matrix metalloproteinase ( MMP ) inhibitors
Seo et al., Biochem Biophys Res Commun 2010
(Cell Transformation, Neoplastic...) :
Galphaq was found to
mediate the UVB induced
HB-EGF secretion by sequential activation of phospholipase C (PLC), protein kinase Cdelta (PKCdelta), and
matrix metaloprotease-2 (MMP-2)
Cheng et al., J Cell Physiol 2012
(MAP Kinase Signaling System) :
These results suggest that BK-induced cell proliferation is mediated through c-Src dependent transactivation of EGFR via
MMP2/9 dependent
pro-HB-EGF shedding linking to activation of Akt and p42/p44 MAPK in corneal fibroblasts