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MAPK7 — UTP23
Text-mined interactions from Literome
Huwiler et al., Br J Pharmacol 2000
:
3. Time courses reveal that ATP and
UTP induce a rapid and transient activation of the
p38-MAPK activity with a maximal activation after 5 min of stimulation which declined to control levels over the next 20 min. 4
Tu et al., Br J Pharmacol 2000
(Glioma...) :
3. In
response to
UTP , both p42 and p44
MAPK were activated in a time- and concentration dependent manner using Western blot analysis with an anti-phospho-p42/p44 MAPK antibody ... Both DNA synthesis and phosphorylation of
MAPK in
response to
UTP were attenuated by tyrosine kinase inhibitors, genistein and herbimycin A, protein kinase C ( PKC ) inhibitors, staurosporine and GF109203X, and removal of Ca ( 2+ ) by addition of BAPTA/AM plus EGTA ... 5.
UTP induced [ ( 3 ) H ] -thymidine incorporation and p42/p44
MAPK phosphorylation was completely inhibited by PD98059 ( an inhibitor of MEK1/2 ) ... Furthermore, we showed that overexpression of dominant negative mutants of Ras ( RasN17 ) and Raf ( Raf-301 ) completely suppressed MEK1/2 and p42/p44
MAPK activation
induced by ATP and
UTP ...
UTP mediated
MAPK activation was modulated by Ca ( 2+ ), PKC, and tyrosine kinase associated with cell proliferation in cultured C ( 6 ) glioma cells
Meshki et al., Am J Physiol Cell Physiol 2004
:
ATP and
UTP caused activation of p38
MAPK and ERK1/2 in human neutrophils
Montiel et al., Cell Physiol Biochem 2006
:
ATP, 2-meSATP,
UTP and UDP
cause a rapid and transitory increase in the phosphorylation of
MAPK/ERK
Chang et al., Cell Signal 2008
(MAP Kinase Signaling System) :
UTP and ATP
activated MAPK in a dose- and time dependent manner
Vázquez-Cuevas et al., Reproductive biology and endocrinology : RB&E 2010
(MAP Kinase Signaling System) :
It was found that
UTP increased
MAPK phosphorylation by up to 550 % with an EC50 of 3.34 +/- 0.92 and 1.41 +/- 0.67 microM, for p44 and p42, respectively ; these increases were blocked by suramin
Huwiler et al., Br J Pharmacol 1994
:
Activation of
mitogen activated protein kinase by both ATP and
UTP is dose-dependently attenuated by the P2-receptor antagonist, suramin
Graham et al., Biochem J 1996
:
We have investigated the mechanisms that bring about the termination of
mitogen activated protein kinase ( MAP kinase ) activation in
response to
UTP in EAhy 926 endothelial cells
Graham et al., Br J Pharmacol 1996
:
Stimulation by the nucleotides, ATP and
UTP of
mitogen activated protein kinase in EAhy 926 endothelial cells
King et al., Neuroscience 1996
:
UTP and 2-methylthioATP
stimulated mitogen activated protein kinase to the same extent as ATP, although UTP was less potent than either ATP or 2-methylthioATP