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Haskó et al., Immunology 2001
:
Sulphasalazine inhibited the
LPS/IFN-gamma induced production of both interleukin-12 (IL-12)
p40 and p70
Kopp et al., J Invest Dermatol 2001
(Disease Models, Animal...) :
As induction of interferon-gamma is a major function of interleukin-12, we tested the in vitro ability of transgenic
p40 to
induce interferon-gamma
Padigel et al., J Immunol 2001
(Leishmaniasis, Cutaneous) :
At wk 9 of infection, we
detected similar levels of IL-4,
IFN-gamma , IL-12p40, and IL-12Rbeta2 mRNA in draining lymph nodes of healing C57BL/6, CD28 ( -/- ), and CD40L ( -/- ) CD28 ( -/- ) mice, whereas CD40L ( -/- ) mice had increased mRNA levels for IL-4 but reduced levels for IFN-gamma,
IL-12p40 , and IL-12Rbeta2
Haskó et al., J Pharmacol Exp Ther 2002
:
In the current study, we investigated the involvement of ABC transporters in the regulation of lipopolysaccharide (LPS) and/or
interferon (IFN)-gamma induced interleukin (IL)-12
p40 and tumor necrosis factor (TNF)-alpha production, nitric oxide formation, as well as major histocompatibility complex II up-regulation in macrophages
Petro et al., Int Immunopharmacol 2003
:
Expression of p35 and
p40 in
response to lipopolysaccharide (LPS) and
interferon (IFN)-gamma requires activation of nuclear factor-kappa-B (NF-kappaB) and interferon regulatory factor ( IRF ) transcription factors
Zhu et al., J Biol Chem 2003
:
However, molecular mechanisms through which
interferon (IFN)-gamma and bacterial products synergistically
activate IL-12
p40 gene expression are less clear
Lew et al., Br J Dermatol 2004
(Disease Progression...) :
The mRNA expression of keratin 16, CD25, IFN-gamma, IL-12
p40 , signal transducer and activator of transcription-1, inducible nitric oxide synthase, IL-8, macrophage inflammatory protein-3alpha, monocyte chemoattractant protein-1, S100A12, IFN-gamma-inducible protein of 10 kDa, IFN-inducible T-cell alpha-chemoattractant and monokine
induced by
IFN-gamma was increased in the lesions of both LP psoriasis and SP psoriasis
Nakahara et al., Clin Exp Immunol 2005
(Neoplasms) :
However, IL-1beta, but not
IFN-gamma ,
induced IL-12
p40 production by DCs without enhancing phenotypic maturation
An et al., Inflammation 2004
:
In this study, using mouse peritoneal macrophages, we have examined whether XF affects nitric oxide ( NO ), tumor necrosis factor (TNF)-alpha, and interleukin
(IL)-12p40 production
induced by
interferon (IFN)-gamma and lipopolysaccharide (LPS)
Wheeler et al., Immunology 2006
(Encephalomyelitis, Autoimmune, Experimental) :
There was greater expression of
IL-12/23p40 by antigen presenting cells in these mice, and in vitro, TNFR1-/- antigen presenting cells
induced greater secretion of
IFN-gamma but not interleukin (IL)-17 when cultured with primed T cells than did WT antigen presenting cells
Nakano et al., Blood 2007
(Bacterial Infections...) :
The transcription levels of p35 and
p40 were increased by
stimulation of BMMCs with
IFN-gamma/lipopolysaccharide (LPS)
Qi et al., Sci China C Life Sci 2000
:
Promoting
effect of
IFN-gamma on the expression of LPS induced IL-12
p40 and p35 mRNA in murine suppressor macrophages ... It was found that
IFN-gamma strongly
enhanced the LPS induced IL-12
p40 and p35 mRNA expression ... Taken together, the data suggest : ( i )
IFN-gamma/LPS could strongly
induce the expression of IL-12
p40 and p35 mRNA ; both the expression levels were equal ; this phenomenon coincided with the high-level secretion of IL-12 p70 induced by IFN-gamma/LPS ; ( ii ) NF-kappaB signal pathway is essential for IFN-gamma/LPS to induce IL-12 mRNA expression ; ( iii ) by blocking the degradation of IkappaB, the PSI suppresses the IL-12 p40/p35 mRNA expression induced by LPS and IFN-gamma/LPS ; ( iv ) NF-kappaB signal may not be involved in the mechanism by which IFN-gamma enhanced the expression of the LPS induced IL-12 p40/p35 mRNA
Hayes et al., Blood 1995
:
Time course experiments demonstrated independent
regulation of
p40 and p35 by
IFN-gamma and LPS
Gillessen et al., Eur J Immunol 1995
:
The (
p40 ) 2 was 25- to 50-fold more active than the p40 monomer in causing specific, dose dependent inhibition of IL-12 induced mouse concanavalin A ( Con A ) blast proliferation and could also
inhibit IL-12 induced
interferon-gamma (IFN-gamma) secretion by mouse splenocytes and IL-12 dependent activation of mouse NK cells
Mattner et al., Eur J Immunol 1993
:
Furthermore, the synthesis of
interferon (IFN)-gamma by mouse splenocytes activated with IL-2 and IL-12 was
suppressed by
IL-12p40
Piccotti et al., J Immunol 1997
:
To determine which T cell population produced enhanced levels of
IFN-gamma in
response to
p40 homodimer, CD4+ or CD8+ T cells were depleted from the MLC
Isler et al., Am J Respir Cell Mol Biol 1999
:
Both p35 and
p40 mRNA levels were induced by lipopolysaccharide (LPS) and were further
increased by
interferon-gamma (IFN-gamma)