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IDO2 — IFNG

Pathways - manually collected, often from reviews:

• KEGG African trypanosomiasis: IFNG → IDO1/IDO2 (gene expression, expression)

Text-mined interactions from Literome

Du et al., J Interferon Cytokine Res 2000 : Analysis of transcription factors regulating induction of indoleamine 2,3-dioxygenase by IFN-gamma
Widner et al., Adv Exp Med Biol 1999 : Tryptophan is converted to kynurenine by the action of the enzyme indoleamine 2,3-dioxygenase induced by interferon-gamma (IFN-gamma)
Kudo et al., Mol Hum Reprod 2000 : The effect of interferon-gamma on indoleamine 2,3-dioxygenase , a tryptophan catabolizing enzyme, was studied in cultured human placental chorionic villi ... The activity of indoleamine 2,3-dioxygenase was markedly stimulated by interferon-gamma in a time- and concentration dependent manner ... The level of indoleamine 2,3-dioxygenase mRNA expression ( determined by reverse transcription-polymerase chain reaction ) was also enhanced by interferon-gamma ... Interleukin-4 showed a dose dependent inhibitory effect on interferon-gamma induced stimulation of indoleamine 2,3-dioxygenase activity and mRNA expression
Widner et al., Immunobiology 2000 (Lupus Erythematosus, Systemic) : IFN-gamma stimulates the enzyme indoleamine ( 2,3 ) -dioxygenase ( IDO ) converting tryptophan to the metabolite kynurenine which in macrophages is subsequently degraded to other, partly neurotoxic compounds like quinolinic acid, and finally to nicrotinamides
Amann et al., Mediators Inflamm 2001 (Disease Models, Animal...) : In human monocytes/macrophages, interferon-gamma induces increased production of neopterin and an enhanced activity of indoleamine 2,3-dioxygenase , which degrades tryptophan via the kynurenine pathway
Widner et al., J Neural Transm 2002 (Parkinson Disease) : In parallel, IFN-gamma induces indoleamine 2,3-dioxygenase which degrades 1-tryptophan to kynurenine
Chiarugi et al., J Leukoc Biol 2003 : IFN-gamma ( 100 U/ml ) not only increased the synthesis and release of NO and TNF-alpha from these cells but also induced indoleamine-2,3-dioxygenase , the rate limiting enzyme of TRP catabolism
Wirleitner et al., Eur J Clin Invest 2003 (Coronary Disease) : Cytokine interferon-gamma , which is released during cell mediated immune responses, induces indoleamine ( 2,3 ) -dioxygenase ( IDO ), an enzyme degrading tryptophan to kynurenine
Sarkhosh et al., J Cell Biochem 2003 : Immune cell proliferation is suppressed by the interferon-gamma induced indoleamine 2,3-dioxygenase expression of fibroblasts populated in collagen gel ( FPCG )
Schroecksnadel et al., J Rheumatol 2003 (Arthritis, Rheumatoid) : Activation of the enzyme indoleamine- ( 2,3 ) -dioxygenase ( IDO ) by interferon (IFN)-g leads to enhanced tryptophan conversion to kynurenine
Saito et al., Neuroscience 1992 : Interferon-gamma , pokeweed mitogen and lipopolysaccharide induced indoleamine-2,3-dioxygenase , the first enzyme of the kynurenine pathway, and increased both L-kynurenine and quinolinic acid concentrations of brain and systemic tissues, particularly in the lung, gastrointestinal tract and spleen
Weiss et al., Eur J Haematol 2004 (Anemia...) : In macrophages, IFN-gamma strongly induces indoleamine ( 2,3 ) -dioxygenase , an enzyme which degrades tryptophan (trp) to kynurenine ( kyn )
Kudo et al., J Reprod Immunol 2004 : Interferon-gamma added to villous explants markedly stimulates indoleamine 2,3-dioxygenase protein expression in macrophages
Seo et al., Nat Med 2004 (Arthritis, Rheumatoid) : Both anti-interferon-gamma and 1-methyltryptophan, a pharmacological inhibitor of indoleamine 2,3-dioxygenase , reversed the anti-4-1BB effect
Hansen et al., Int J Parasitol 2004 (Malaria, Cerebral...) : These results suggest that interferon-gamma dependent indoleamine 2,3-dioxygenase expression is part of a normal systemic host response to the parasite, perhaps performing some tissue protective functions that may become deranged under some circumstances and contribute to the pathogenesis of cerebral malaria
Nelson et al., Proc Natl Acad Sci U S A 2005 (Chlamydia Infections) : In human epithelial cells, IFN-gamma induces indoleamine 2,3-dioxygenase expression that inhibits chlamydial growth by depleting host tryptophan pools ... Conversely, in murine epithelial cells IFN-gamma induces expression of p47 GTPases, but not indoleamine 2,3-dioxygenase
Hunt et al., Int J Parasitol 2006 (Disease Models, Animal...) : Interferon-gamma , a cytokine known to be produced in malaria infection, induces increased expression, by microvascular endothelial cells, of the haem enzyme indoleamine 2,3-dioxygenase , the first enzyme in the kynurenine pathway of tryptophan metabolism
Noakes et al., Clin Exp Med 2006 (Eosinophilia...) : It has been suggested that this is due to activation of indoleamine 2,3-dioxygenase by interferon-gamma
Schroecksnadel et al., Curr Vasc Pharmacol 2006 (Atherosclerosis...) : Interferon-gamma also stimulates the enzyme indoleamine-2,3-dioxygenase , which degrades tryptophan to kynurenine
Sarkar et al., Diabetes 2007 : Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human islets
Jung et al., FEBS Lett 2007 : Differential regulation of indoleamine 2,3-dioxygenase by lipopolysaccharide and interferon gamma in murine bone marrow derived dendritic cells
Pfaff et al., Int J Parasitol 2008 (Parasitemia...) : Impact of foetus and mother on IFN-gamma induced indoleamine 2,3-dioxygenase and inducible nitric oxide synthase expression in murine placenta following Toxoplasma gondii infection
Cuffy et al., J Immunol 2007 : Induction of indoleamine 2,3-dioxygenase in vascular smooth muscle cells by interferon-gamma contributes to medial immunoprivilege
Cano et al., Neurosci Lett 2008 (AIDS Dementia Complex) : Interestingly, IFN-gamma , but not IFN-alpha/beta, increased expression and activity of the tryptophan catabolizing enzyme indoleamine ( 2,3 ) -dioxygenase
Zhang et al., Zhong Yao Cai 2008 (Breast Neoplasms...) : [ Curcumin inhibiting the expression of indoleamine 2,3-dioxygenase induced by IFN-gamma in cancer cells ]
O'Connor et al., J Neurosci 2009 : Interferon-gamma and tumor necrosis factor-alpha mediate the upregulation of indoleamine 2,3-dioxygenase and the induction of depressive-like behavior in mice in response to bacillus Calmette-Guerin
Yamada et al., J Neurochem 2009 (Alzheimer Disease) : Proinflammatory cytokine interferon-gamma increases induction of indoleamine 2,3-dioxygenase in monocytic cells primed with amyloid beta peptide 1-42 : implications for the pathogenesis of Alzheimer 's disease
Mailankot et al., Int J Biochem Cell Biol 2010 : Induction of indoleamine 2,3-dioxygenase by interferon-gamma in human lens epithelial cells : apoptosis through the formation of 3-hydroxykynurenine
Takikawa et al., J Immunol 1990 (Neoplasms, Experimental) : IFN-gamma is the inducer of indoleamine 2,3-dioxygenase in allografted tumor cells undergoing rejection
Fuchs et al., J Interferon Res 1990 (HIV Infections) : From the data it appears that reduced tryptophan in patients may result from induction of indoleamine ( 2,3 ) -dioxygenase by IFN-gamma
Dai et al., J Biol Chem 1990 : Regulation of indoleamine 2,3-dioxygenase gene expression in human fibroblasts by interferon-gamma
Pfefferkorn et al., J Interferon Res 1986 : In this report, we show that IFN-gamma induced an indoleamine 2,3-dioxygenase in human fibroblasts that converts tryptophan to N-formylkynurenine ... The induction of indoleamine 2,3-dioxygenase by IFN-gamma was inhibited by treatment of the cultures with either actinomycin D or cycloheximide, and thus was dependent on both RNA and protein synthesis ... The indoleamine 2,3-dioxygenase induced by IFN-gamma appeared to differ from other mammalian enzymes that degrade tryptophan ... The indoleamine 2,3-dioxygenase induced by IFN-gamma did not appear to play a major role in the antiviral activity of IFN-gamma in human fibroblasts
Werner-Felmayer et al., Biochim Biophys Acta 1989 : Interferon-gamma regulated only the activity of indoleamine 2,3-dioxygenase
Feng et al., Proc Natl Acad Sci U S A 1989 : Two of the mutant lines ( ME-IR3b and ME-IR6g ) examined had significantly lower induction levels of the L-tryptophan ( L-Trp ) degradative enzyme indoleamine 2,3-dioxygenase activity in response to IFN-gamma
Werner et al., Biochem J 1989 : Parallel induction of tetrahydrobiopterin biosynthesis and indoleamine 2,3-dioxygenase activity in human cells and cell lines by interferon-gamma
de la Maza et al., Cancer Res 1988 : The mechanisms involved in this antiproliferative activity are poorly understood, but it is known that IFN-gamma can induce indoleamine 2,3-dioxygenase , which enhances tryptophan metabolism and thus depletes the cellular pool of this amino acid
Takikawa et al., J Biol Chem 1988 (Carcinoma, Squamous Cell...) : Induction by interferon-gamma of indoleamine 2,3-dioxygenase ( a tryptophan degradation enzyme ) was examined with 11 human cell lines
Malone et al., J Rheumatol 1994 : Interferon gamma induced production of indoleamine 2,3 dioxygenase in cultured human synovial cells
Däubener et al., Eur J Immunol 1995 (Glioblastoma) : Secondly, we show that heparin inhibits the IFN-gamma induced toxoplasmostasis within 86HG39 cells in a dose dependent fashion, and thirdly that heparin inhibits the IFN-gamma mediated induction of the tryptophan degrading enzyme indoleamine 2,3-dioxygenase
Heyes et al., Biochem J 1997 (Astrocytoma) : Stimulation with interferon gamma substantially increased indoleamine 2,3-dioxygenase activity and L-kynurenine production in primary peripheral blood macrophages and fetal brains ( astrocytes and neurons ), as well as cell lines derived from macrophage/monocytes ( THP-1 ), U373MG astrocytoma, SKHEP1 liver and lung ( MRC-9 )
MacKenzie et al., J Infect Dis 1998 : Interferon-gamma induced activation of indoleamine 2,3-dioxygenase in cord blood monocyte derived macrophages inhibits the growth of group B streptococci ... Interferon-gamma induced the activation of indoleamine 2,3-dioxygenase in MDM and inhibited the growth of GBS