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CSF2 — IFNG

Text-mined interactions from Literome

Takayama et al., J Invest Dermatol 1999 : Both GM-CSF and TNF-alpha induced the migration of human Langerhans cells in vitro, whereas IL-1beta, IL-2, IL-10, IL-12, and IFN-gamma had no effect on Langerhans cell migration
Dey et al., Biochim Biophys Acta 2000 : The induction appears to be transcriptional activation of the D cyclin genes, since indirect events such as IFNgamma induced colony stimulating factor-1 (CSF-1) autocrine stimulation, alteration of D1 and D2 mRNA stability and lipopolysaccharide contamination in commercial IFNgamma preparations play no roles
Pang et al., Mol Cell Biol 2000 (Fanconi Anemia) : In addition, glutathione S-transferase fusion genes encoding normal FANCC but not a mutant FANCC bearing an inactivating point mutation ( L554P ) bound to STAT1 in lysates of IFN-gamma stimulated B cells and IFN-, granulocyte-macrophage colony stimulating factor- and stem cell factor stimulated MO7e cells
Tachimoto et al., J Allergy Clin Immunol 2000 : In contrast, IFN-gamma inhibited FcepsilonRI induced production of MIP-1alpha, IL-8, and GM-CSF
Lee et al., Arch Pharm Res 2000 : High level of macrophage-colony stimulating factor ( M-CSF ) and interleukin (IL)-6 was detected in the TFGD-culture supernatant, whereas granulocyte/macrophage-colony stimulating factor ( GM-CSF ), IL-3, IL-4, IL-5, IL-13, or interferon (IFN)-gamma was undetectable
Riopel et al., Infect Immun 2001 (Anemia...) : GM-CSF may also regulate IFN-gamma and TNF-alpha production and activity in response to infection
Crane et al., Cell Immunol 2001 (Calcium Signaling) : Regulation of granulocyte-macrophage colony stimulating factor in human retinal pigment epithelial cells by IL-1beta and IFN-gamma ... IFN-gamma inhibition of the GM-CSF response to IL-1beta acted via NF-kappaB, reducing the translocation of NF-kappaB to the nuclei of RPE cells treated with IL-1beta and IFN-gamma
Kamińska et al., Arch Immunol Ther Exp (Warsz) 2001 (Leukemia, Myeloid, Acute) : In control blood cells ( 25 healthy persons ) GM-CSF enhanced PHA induced IFN-gamma but did not influence IFN-alpha production
Moore et al., J Virol 2002 : IL-12 induced the greatest increase in IFN-gamma and immunoglobulin G responses to Nef, and GM-CSF induced the strongest IFN-gamma and CTL responses to Env
Furr et al., Equine Vet J 2001 (Central Nervous System Protozoal Infections...) : In addition, the effect of CSF from normal and EPM affected horses on the production of interferon-gamma (IFN-gamma) by PHA-P stimulated PBMCs from normal horses was investigated using a bioassay ... It was found that CSF from normal and EPM affected horses enhanced IFN-gamma activity from PHA-P stimulated peripheral blood mononuclear cells ( P < or = 0.05 ) ; however, the response to CSF from EPM affected horses was no different than the response to CSF from normal horses
Sabatini et al., J Asthma 2002 : The inhibitory effects of Bud preexposure on IFN-gamma induced ICAM-1 expression and GM-CSF release were then compared with those of a continuous exposure to the drug during IFN-gamma stimulation
Xie et al., Zhongguo Shi Yan Xue Ye Xue Za Zhi 2002 (Leukemia, Myeloid) : [ Proliferation and IFN-gamma secretion of autologous T lymphocytes stimulated by myeloid leukemia cells induced with rhGM-CSF and rhIL-4 ] ... To observe the proliferation of T lymphocytes stimulated by CML and AML cells which were induced by rhGM-CSF and rhIL-4, and the secretion of IFN-gamma from proliferated T lymphocytes, the expression of CD80, CD86 and HLA-DR on CML and AML cells induced by GM-CSF and IL-4 was assayed by flow cytometry in vitro
Sallerfors et al., Eur J Haematol 1992 : IL-3 induced a minor secretion of GM-CSF whereas TNF, G-CSF, M-CSF and IFN-gamma were unable to induce GM-CSF secretion
Zhou et al., J Biol Chem 2003 : IFNgamma induced MMP-1 in the presence of GM-CSF through the stimulation of TNFalpha production through a mechanism involving both p38 and ERK1/2 MAPKs, in which GM-CSF stimulated ERK1/2 whereas IFNgamma activated p38 ... Thus IFNgamma in the presence of GM-CSF and/or TNFalpha differentially regulates monocyte MMPs through induction of TNFalpha and a novel mechanism involving caspase 8 that is independent of apoptosis
Grattage et al., Immunol Cell Biol 1992 : The major findings were : PMA increased cell surface FcRI, FcRII and CD11b, but decreased HLA ; PMA caused a fivefold increase in all three FcRII RNA transcripts ( 2.5, 1.5 and 0.9 kb ) in Northern analysis ; IFN gamma , IFN alpha and GM-CSF increased the expression of FcRI and II, and there was no effect with IL-1 beta, IL-2, TNF alpha or TNF beta ( only GM-CSF increased the expression of CD11b ) ; all cytokines further increased FcRI and FcRII expression in the presence of PMA ; HLA expression was also increased in the presence of PMA, IFN alpha and IFN gamma ; dexamethasone reduced the levels of FcRI and II in cells stimulated with PMA with or without cytokines
Hallek et al., Blood 1992 : Nuclear run-on assays and mRNA half-life studies showed that IFN-gamma modestly enhanced the transcription of the GM-CSF-R beta gene and stabilized the GM-CSF-R beta mRNA, with the latter mechanism predominant ... Pretreatment of the monocytes with cycloheximide did not abrogate the increase of GM-CSF-R beta mRNA expression induced by IFN-gamma , indicating that de novo protein synthesis was not required for this activity
Hamilton et al., Immunology 1992 : Granulocyte-macrophage (GM)-CSF in the LPS treated monocyte supernatants was also quantitated by ELISA but its levels were somewhat lower than for G-CSF ; IL-4, dexamethasone and IFN-gamma had similar effects on GM-CSF levels as on G-CSF levels
Harada et al., J Interferon Cytokine Res 2004 : In contrast, neutralizing GM-CSF using anti-GM-CSF monoclonal antibody ( mAb ) significantly inhibited IFN-gamma , TNF-alpha, and IL-12p70 elicited by SCG
Tsuchimoto et al., Immunol Invest 2004 : We observed that IFN-gamma significantly increases the production of colony stimulating factor-1 (CSF-1) by a human lung carcinoma cell line, A549
Nagi-Miura et al., Atherosclerosis 2006 (Arteritis) : In contrast, anti-GM-CSF significantly reduced the production of TNF-alpha and IFN-gamma
Gruber et al., Cell Immunol 1992 : Production of macrophage colony stimulating factor ( M-CSF ) by human monocytes is differentially regulated by GM-CSF, TNF alpha, and IFN-gamma
Oishi et al., Cytokine 2006 : The rhG-CSF induced a pre-PHx downregulation of the IL-12p70 protein levels, while also promoting the post-PHx reduction of the protein levels of IL-12p70 and IFN-gamma
Harada et al., Microbiol Immunol 2006 (Leukopenia) : Neutralizing GM-CSF significantly inhibited the induction of IFN-gamma , TNF-alpha and IL-12p70 by SCG
Lopez et al., J Cell Physiol 1990 (Leukemia, Myelogenous, Chronic, BCR-ABL Positive) : Specificity studies under conditions that prevent receptor internalization showed that the binding of IL-3, GM-CSF , and IL-5 was not inhibited by tumor necrosis factor (TNF)-alpha, IL-1 beta, interferon (IFN)-gamma , or G-CSF
Kilinc et al., J Immunol 2006 (Adenocarcinoma, Bronchiolo-Alveolar...) : IL-12/GM-CSF treatment promoted a rapid up-regulation of CD43 and CD69 on CD8+ effector/memory T cells, augmented their ability to produce IFN-gamma , and restored granzyme B expression
Denis et al., Clinical and vaccine immunology : CVI 2007 (Tuberculosis, Bovine) : IL-2 and GM-CSF promoted IFN-gamma release whether antigen was present or not
Kasper et al., J Interferon Cytokine Res 2007 : EMSA showed that GM-CSF inhibited IFN-alpha induced and IFN-gamma induced IFN-gamma activator sequence ( GAS ) binding activity
Kan et al., Blood 1991 : IFN-gamma also inhibited M-CSF- , GM-CSF-, or IL-3 stimulated [ 3H ] -thymidine incorporation in highly enriched GM-CFC
Burdach et al., J Clin Invest 1991 : GM-CSF and IFN-gamma release from activated T cells increased four- to fivefold in response to 1 nM IL-2 and IL-2 augmented both GM-CSF and IFN-gamma mRNA
Vassiliadis et al., Exp Hematol 1991 (Leukemia, Promyelocytic, Acute) : It has been shown that 37 % of the bulk HL-60 cell population is induced by immune interferon (IFN) to express functional colony stimulating factor-1 (CSF-1) receptors
Breen et al., J Immunol 1991 : In the presence of both CSF , IFN-gamma increased the colony count by around 25 to 40 %, so that the numbers were greater than the combined total of CSF-1 plus GM-CSF added separately
Dale et al., Dev Med Child Neurol 2009 (Central Nervous System Diseases...) : Cerebrospinal fluid (CSF) neopterin production is increased by interferon-gamma stimulation and appears to act as a marker of intrathecal immune activation
Yuan et al., Eur J Cancer Prev 2009 (Breast Neoplasms) : We also found that CD4 positive and CD8 positive lymphocytes were detected only in tumors grown in rBCG-MVNTR4/8-CSF immunized animals, and strong IFN-gamma responses were induced by immunization with rBCG-MVNTR4-CSF and rBCG-MVNTR8-CSF vaccines
Tassi et al., PloS one 2009 (Disease Progression...) : We found that only the combination of IL-12 and IL-27 modified the polarization of Th2 effectors by both reduction of IL-5, GM-CSF and IL-13 and induction of IFN-gamma production, which lasted after cytokine removal
Kamijo et al., J Immunol 1990 (Leukemia, Myeloid) : Although IFN-gamma, IL-6, granulocyte CSF , and granulocyte-macrophage CSF induced nitroblue tetrazolium reducing activity of U-937 cells, only IFN-gamma , and TNF induced it synergistically in combination with TGF-beta 1
Bermudez et al., J Leukoc Biol 1990 : These results indicate that : 1 ) GM-CSF can activate macrophages to inhibit intracellular growth or kill MAC ; 2 ) killing may be augmented by TNF ; and 3 ) IFN gamma may impair GM-CSF dependent macrophage activation
Zimmer et al., J Immunol 1990 : IFN-gamma induces Ia expression on perhaps all murine macrophages, whereas IL-4, granulocyte-macrophage CSF , and CSF-1 induce Ia on restricted sets of macrophages
Chantry et al., Cytokine 1990 : By itself, GM-CSF did not induce surface class II expression on the human monocytic tumour cell line THP-1, whereas it synergized with IFN-gamma to induce surface expression
Fischer et al., J Immunol 1990 : Regulation of IFN-gamma-receptor expression in human monocytes by granulocyte-macrophage colony stimulating factor ... The regulation of human IFN-gamma receptor ( IFN-gamma-R ) expression by granulocyte-macrophage CSF (GM-CSF) was investigated
Oster et al., J Biol Regul Homeost Agents 1988 : Whereas secretion of these molecules by monocytes is negligible in a quiescent state, activation of monocytes with Interferon-gamma (IFN-gamma) results in mRNA accumulation and subsequent protein secretion of CSF for granulocytes ( G-CSF ) and for monocytes ( M-CSF )
Gerrard et al., J Interferon Res 1989 : Interleukin 1 (IL-1) or granulocyte-monocyte colony stimulating factor ( GM-CSF ) did not enhance the activity of IFN-gamma
Alvaro-Gracia et al., J Exp Med 1989 (Arthritis, Rheumatoid) : The effect of GM-CSF on HLA-DR was not mediated by the generation of IFN-gamma in vitro because it was not blocked by anti-IFN-gamma mAb
Herrmann et al., J Immunol 1986 : This effect could be abrogated by specific neutralizing monoclonal antibody to IFN-gamma and was restricted to monocytes, as resting T cells failed to secrete detectable CSF-GM in response to IFN-gamma
Heidenreich et al., Behring Inst Mitt 1988 : The effect of granulocyte/macrophage colony stimulating factor ( GM-CSF ) on macrophage activation by interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS) was studied in a murine model system
Galy et al., Thymus 1993 (Cell Transformation, Viral) : SV40 cells were also regulated by IFN-gamma which induced MHC class II antigens and inhibited the IL-1 induced GM-CSF production
Ogawa et al., Cell Struct Funct 1994 : Differential expression of colony stimulating factor (CSF) in murine macrophage clones : interferon-gamma mediated inhibition of CSF production ... However, in either case, IFN-gamma completely inhibited LPS induced production of active CSF of the M phi clones, which was observed even in IFN-gamma pretreatment, and also abrogated autoactivation of GM-CSF
Gollnick et al., J Interferon Cytokine Res 1995 : The expression of class II antigens on B cell and macrophage APC is induced by IFN-gamma and IL-4, and GM-CSF induces class II expression on macrophages ( M phi ) ... Nuclear run-on experiments demonstrated that the inhibitory effects of TGF-beta on GM-CSF- and IL-4 induced Ia antigen expression were primarily posttranscriptional and augmentation of IFN-gamma by TGF-beta was largely transcriptionally regulated
Yang et al., Mol Immunol 1995 : cDNAs containing sequences which did not match published sequences were used to probe Northern blots prepared from both unstimulated and IFN-gamma activated GM-CSF- and CSF-1 derived m phi
Heidenreich et al., J Neuroimmunol 1994 (AIDS Dementia Complex...) : Serum and CSF levels of sICAM-1 correlated with neopterin levels, a marker of interferon-gamma mediated macrophage activation and CSF sICAM-1 levels were inversely correlated to numbers of CD4+ T cells
Steel et al., J Infect Dis 1994 (Onchocerciasis) : Six months after the first dose of ivermectin, there were increases in the IL-2, IL-4, IL-5, and interferon-gamma responses to mitogen and in the GM-CSF and IL-10 responses to OvA
van de Loosdrecht et al., Leukemia 1994 (Acute Disease...) : The growth stimulatory effects of non activated monocytes on immature AML cells could be abrogated in the presence of IFN gamma or IL-3 and GM-CSF
Akahane et al., Exp Hematol 1993 : In the present study, we show that GM-CSF production in murine aorta derived vascular endothelial cells is regulated by two cytokines : interleukin-1 (IL-1), which induces the production of GM-CSF, and interferon gamma (IFN-gamma) , which downregulates this production ... These data suggest that IL-1 induced GM-CSF expression in endothelial cells is regulated at the posttranscriptional level and that IFN-gamma specifically inhibits GM-CSF expression via destabilization of the mRNA
Gosselin et al., J Immunol 1993 : In addition, granulocyte/macrophage CSF (GM-CSF), IFN-gamma , and IL-3 can induce class II on pure cultures of PMN, with GM-CSF appearing to be the most potent of the three cytokines
Ozawa et al., Eur J Immunol 1996 : Finally, we studied the effects of IFN-gamma and IL-10 on GM-CSF production by epidermal keratinocytes ( KC ) ... We could show that only IFN-gamma , but not IL-10, suppressed GM-CSF production by KC
Kruger et al., Immunology 1996 : The cytokines interleukin-1 beta (IL-1 beta) and IL-2 strongly enhanced GM-CSF production, while IL-4, IL-6, GM-CSF, interferon-gamma (IFN-gamma) and tumour necrosis factor (TNF) had no effect
Akagawa et al., Blood 1996 : Rather, IFN-gamma antagonized the effect of IL-4 and suppressed the DC and MGC formation induced by GM-CSF + IL-4 and M-CSF + IL-4, respectively
Taylor et al., Neuroimmunomodulation 1996 : Human and rabbit CSF enhanced antigen stimulated lymph node T cell proliferation and human CSF suppressed IFN-gamma production
Conti et al., J Biol Chem 1997 : Its biological activity is pleiotropic, and, so far, it has been shown to induce interferon-gamma production in Th1 cells, to augment the production of granulocyte-macrophage-CSF , and to decrease that of interleukin-10 (IL-10)
Saunders et al., Br J Pharmacol 1997 : In contrast, neither LPS nor IFN gamma produced a significant increase in GM-CSF release
Hauber et al., Cell Immunol 1997 : We show that gene expression of IL-1 alpha, IL-1 beta, IL-6, granulocyte-colony stimulating factor , and IL-10 was induced in both cell fractions, whereas increased mRNA levels of interferon-gamma and the inducible nitric oxide synthase were exclusively detected in the patients ' nonadherent MNCs
Alford et al., Biochem Biophys Res Commun 1997 : The macrophage-colony stimulating factor receptor, c-fms, is induced by IL-2 in monocytes and is suppressed by LPS, LPS plus IFN-gamma , phorbol esters, and colony stimulating factor in monocytes/macrophages
Okano et al., Int Arch Allergy Immunol 1998 (Asthma) : IL-12 enhanced IFN-gamma production and inhibited the production of IL-5 but not of GM-CSF by Df-stimulated MNCs from asthmatic patients