◀ Back to FGR

FGR — SRC

Pathways - manually collected, often from reviews:

• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr)(cy) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) (translocation, collaborate)
  
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) → SRC/Hck/c-Fgr (FGR/HCK/SRC) (modification, collaborate)
  
• BioCarta roles of ß arrestin dependent recruitment of src kinases in gpcr signaling: Arrestin/SRC/Hck/c-Fgr complex (ARRB1-FGR_HCK_SRC) → Ligand/GPCR(+)/Arrestin/(SRC/Hck/c-Fgr)(cy) complex (CCL4_EDN1__AGT_CCL11_CXCL12_F2_compound:CAS66575-29-9_compound:CAS745-65-3-ARRB1-FGR_HCK_SRC) (degradation, collaborate)
  
• NCI Pathway Database Ephrin B reverse signaling: Ephrin B1/EPHB1-2/Src Family Kinases complex (EFNB1-EPHB1_EPHB2-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Palmer et al., Mol Cell 2002
  Evidence: mutant phenotype, physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Manes et al., Mol Cell Biol 2000, Blake et al., Mol Cell Biol 2000, Zhao et al., Mol Cell Biol 2006, Kypta et al., Cell 1990, Sirvent et al., Oncogene 2008, Ouyang et al., Proc Natl Acad Sci U S A 2008, Ralston et al., Proc Natl Acad Sci U S A 1985, Barone et al., Nature 1995, Alonso et al., J Biol Chem 1995, Hansen et al., Biochem Biophys Res Commun 1997, Roche et al., Curr Biol 1998
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database Glypican 1 network: Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Bianco et al., Cancer Res 2003
  Evidence: physical interaction, other species
• NCI Pathway Database Alpha-synuclein signaling: Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  
• NCI Pathway Database PDGFR-beta signaling pathway: PDGF-BB/PDGFRB (dimer)/RasGAP/Src Family Kinases complex (PDGFRB-RASA1-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-PDGFB) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Schlesinger et al., Biochem J 1999
  Evidence: physical interaction
• NCI Pathway Database EPHA forward signaling: Ephrin A5/EPHA3-4-5-6-7/Src Family Kinases complex (EFNA5-EPHA7_EPHA6_EPHA5_EPHA3_EPHA4-FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Knöll et al., J Neurosci 2004
  Evidence: physical interaction
• NCI Pathway Database PDGFR-beta signaling pathway: Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) → Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Zhao et al., J Exp Med 2001, Zhang et al., Mol Cell 2004, Zhao et al., Mol Cell Biol 2006
  Evidence: assay
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Shan et al., J Biol Chem 1999, Baba et al., Proc Natl Acad Sci U S A 2001, Rawlings et al., Science 1996, August et al., Proc Natl Acad Sci U S A 1997
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database Thromboxane A2 receptor signaling: Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Gao et al., J Pharmacol Exp Ther 2001
  Evidence: mutant phenotype
• NCI Pathway Database Class I PI3K signaling events: Src family/SYK family/BLNK-LAT/BTK-ITK/PLC-gamma complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK-PLCG1_PLCG2) → Src family/SYK family/BLNK-LAT/BTK-ITK complex (FGR_LYN_LCK_YES1_BLK_HCK_SRC_FYN-ZAP70_SYK-BLNK_LAT-ITK_BTK) (modification, collaborate)
  Perez-Villar et al., J Immunol 1999, Rodriguez et al., Biochem J 2003, Serrano et al., J Immunol 2005
  Evidence: mutant phenotype, physical interaction, other species
• NCI Pathway Database PDGFR-beta signaling pathway: Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Hobson et al., Science 2001, Rosenfeldt et al., Biochem Soc Trans 2001, Rosenfeldt et al., FASEB J 2001, Catarzi et al., Biochim Biophys Acta 2007
  Evidence: mutant phenotype
• NCI Pathway Database Ephrin B reverse signaling: Src family kinases (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, collaborate)
  Palmer et al., Mol Cell 2002
  Evidence: assay

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Hprd Interaction: SRC — FGR (in vitro) Mandine et al., Biochem Biophys Res Commun 2002*, Yamamoto et al., Mol Hum Reprod 2002*, MacAuley et al., Oncogene 1993*, Ruzzene et al., Eur J Biochem 1997*

Text-mined interactions from Literome

Avizienyte et al., Mol Biol Cell 2004 (Colonic Neoplasms...) : Src SH3/2 domain mediated peripheral accumulation of Src and phospho-myosin is linked to deregulation of E-cadherin and the epithelial-mesenchymal transition
Setiawan et al., Endocrinology 2004 : In conclusion, SRC-1 expression undergoes spatial, temporal, and region-specific regulation during development, and limbic and pituitary SRC-1 and SRC-2 are not regulated by glucocorticoids in late gestation