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CXCL12 — FGF2

Text-mined interactions from Literome

Wang et al., Heart 2006 (Myocardial Infarction...) : Plasma SDF-1 increased significantly from day 3 to day 28, and VEGF-A and FGF-2 increased significantly from day 7 to day 28
Nakayama et al., Blood 2007 : Here, we report that FGF2 reduces SDF-1 secretion and protein content in bone marrow stromal cells ... Blocking experiments identified FGFR1 IIIc as the receptor mediating FGF2 inhibition of SDF-1 expression in bone marrow stromal cells ... Analysis of the mechanisms underlying FGF2 inhibition of SDF-1 production in bone marrow stromal cells revealed that FGF2 reduces the SDF-1 mRNA content by posttranscriptionally accelerating SDF-1 mRNA decay
Nakayama et al., J Natl Cancer Inst 2007 (Disease Models, Animal) : Effect of fibroblast growth factor 2 on stromal cell derived factor 1 production by bone marrow stromal cells and hematopoiesis ... We evaluated the effect of fibroblast growth factor 2 (FGF-2) , the level of which is elevated in patients with clonal myeloid disorders, on bone marrow stromal cell expression of stromal cell derived factor 1 (SDF-1) , a chemokine that is essential for normal hematopoiesis ... Cocultures of human CD34 positive peripheral blood stem cells or mouse pre-B DW34 cells with mouse stromal cells were used to characterize the functional relevance of the effects of FGF-2 on SDF-1 expression ... FGF-2 reduced constitutive SDF-1 mRNA expression and secretion in stromal cells ( SDF-1 levels in supernatants : MS-5 cells cultured for 3 days in medium only versus in medium with FGF-2, 95.4 ng/mL versus 22.2 ng/mL, difference = 73.2 ng/mL, 95 % confidence interval [ CI ] = 60.52 to 85.87 ng/mL ; P = .002, two sided Student 's t test ; S-17 cultured in medium only versus in medium with FGF-2, 203.53 ng/mL versus 32.36 ng/mL, difference = 171.17 ng/mL, 95 % CI = 161.8 to 180.6 ng/mL ; P < .001 )
Yoon et al., J Cell Physiol 2009 : FGF2 stimulates SDF-1 expression through the Erm transcription factor in Sertoli cells ... A blocking experiment also confirmed that FGFR4 is partly responsible for the up-regulation of Erm and SDF-1 induced by FGF2 stimulation in TM4 cells