Ozdamar et al., Science 2005
:
Phosphorylation of Par6 is required for TGFbeta dependent EMT in mammary gland epithelial cells and controls the interaction of Par6 with the E3 ubiquitin ligase Smurf1
Townsend et al., J Biol Chem 2008
:
These data demonstrate a functional role for Par6/Smurf1/RhoA in regulating EMT in endocardial cells
Sánchez et al., Cell Signal 2012
:
Overexpression of wild-type ( wt ) Par6 , but not dominant negative ( dn ) Par6, induced EMT and invasion while targeting Par6 by siRNA inhibited EMT and invasion
Gunaratne et al., Mol Cell Biol 2013
(Carcinoma, Non-Small-Cell Lung...) :
In conclusion, our results suggest that aPKCs cooperate with TGF-ß receptors to regulate phospho-Par6 dependent EMT and cell migration